Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation

被引:8
作者
Dadej, Daniela [1 ]
Szczepanek-Parulska, Ewelina [1 ]
Ruchala, Marek [1 ]
机构
[1] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, PL-61701 Poznan, Poland
关键词
fatty acid-binding protein 4; fetuin-A; retinol binding protein 4; thyroid hormones; obesity; type; 2; diabetes; insulin resistance; atherosclerosis; metabolic diseases; CORONARY-ARTERY CALCIFICATION; SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2; DIABETES-MELLITUS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; PANCREATIC-ISLETS; VITAMIN-A; CARDIOVASCULAR MORTALITY; VASCULAR CALCIFICATION; SERUM CONCENTRATION;
D O I
10.3390/metabo12040300
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders. Interactions between cytokines, particularly liver derived hepatokines and adipokines, secreted from adipose tissue, constitute one of major areas of current research devoted to metabolic dysregulation. The thyroid exerts crucial influence on the maintenance of basal metabolic rate, thermogenesis, carbohydrate and lipid metabolism, while its dysfunction promotes the development of metabolic disorders. In this review, we discuss the interplay between three adipokines: fatty acid binding protein type 4, fetuin-A, retinol binding protein type 4 and thyroid hormones, that shed a new light onto mechanisms underlying atherosclerosis, cardiovascular complications, obesity, insulin resistance and diabetes accompanying thyroid dysfunction. Furthermore, we summarize clinical findings on those cytokines in the course of thyroid disorders.
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页数:18
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