Cognitive and motor functioning in gene carriers for Huntington's disease:: A baseline study

被引：44

作者：

Witjes-Ané, MNW

Vegter-van der Vlis, M

van Vugt, JPP

Lanser, JBK

Hermans, J

Zwinderman, AH

van Ommen, GJB

Roos, RAC

机构：

[1] Rijnland Hosp, Dept Neuropsychol, Liederdorp, Netherlands

[2] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Clin Genet, NL-2300 RC Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Med Stat, NL-2300 RC Leiden, Netherlands

[5] Leiden Univ, Med Ctr, Dept Human Genet, NL-2300 RC Leiden, Netherlands

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2003年 / 15卷 / 01期

关键词：

ASYMPTOMATIC CARRIERS; RISK; IMPAIRMENT; DEMENTIA; MEMORY; MANIFESTATIONS; INDIVIDUALS; SYMPTOMS; PEOPLE; MARKER;

D O I：

10.1176/appi.neuropsych.15.1.7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to investigate, the first changes in cognitive and motor functioning in Huntington's disease. Forty-six gene carriers, not clinically diagnosed for HD, were compared with 88 non-gene carriers. Gene carriers performed significantly worse on the Benton Visual Retention Test. This result was due to a minority of participants who had already developed cognitive impairment. Marginal differences appeared on the motor times of single reaction time measures after correction for motor signs. The findings are discussed in the context of inconsistencies in previous studies and underscore the need for longitudinal research.

引用

页码：7 / 16

页数：10

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