The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

被引：75

作者：

Cildir, Gokhan ^{[1
,2
]}

Pant, Harshita ^{[1
,2
,3
]}

Lopez, Angel F. ^{[1
,2
]}

Tergaonkar, Vinay ^{[1
,2
,4
,5
]}

机构：

[1] Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia

[2] SA Pathol, Adelaide, SA, Australia

[3] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[4] Inst Mol & Cell Biol, Lab NF B Signalling, Singapore, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2017年 / 214卷 / 09期

基金：

英国医学研究理事会;

关键词：

RESPONSE FACTOR-I; CYTOKINE PRODUCTION; INNATE IMMUNITY; BETA-CHAIN; RECEPTOR; IGE; DIFFERENTIATION; EXPRESSION; ROLES; MICE;

D O I：

10.1084/jem.20170910

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.

引用

页码：2491 / 2506

页数：16

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