Long noncoding RNA FAM83H-AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21)

被引：35
作者：
Bi, Yong-Yan [1 ]
Shen, Gang [1 ]
Quan, Yong [1 ]
Jiang, Wei [1 ]
Xu, Fulin [1 ]
机构：
[1] Fudan Univ, Minhang Hosp, Dept Neurosurg, 170 Xin Song Rd, Shanghai 201199, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 11期
关键词：
CDKN1A; EZH2; FAM83H-AS1; glioma; H3K27me3; CELL-PROLIFERATION; LNCRNA FAM83H-AS1; MIGRATION; CANCER; EXPRESSION; CARCINOMA; LSD1; TRANSCRIPTION; METASTASIS; KNOCKDOWN;
D O I：
10.1002/jcp.26813
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Gliomas are the commonest and most aggressive primary malignant tumor in the central nervous system. Long noncoding RNAs (lncRNAs) have been identified to act as crucial regulators in multiple biological processes, including tumorigenesis. FAM83H antisense RNA1 (FAM83H-AS1) has been uncovered to be dysregulated in several cancers. However, the biological role of FAM83H-AS1 in glioma still needs to be investigated. Currently, our findings indicated that FAM83H-AS1 was upregulated in glioma tissues and cell lines and high level of FAM83H-AS1 was associated with poor prognosis of glioma. Loss-of-function assays demonstrated that silenced FAM83H-AS1 obviously suppressed cell proliferation via regulating the cell-cycle distribution and cell apoptosis rate, and mechanistic experiments revealed that FAM83H-AS1 could epidemically silence CDKN1A expression through recruiting EZH2 to the promoter of CDKN1A, thereby influencing the cell cycle and proliferation. Collectively, our findings suggested that FAM83H-AS1 participated in the progression of glioma and might act as a potential therapeutic target and prognosis biomarker for human glioma.
引用
收藏
页码：8896 / 8907
页数：12
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