Diminished Expression of MiR-15a Is an Independent Prognostic Marker for Breast Cancer Cases

被引：0

作者：

Shinden, Yoshiaki ^{[1
]}

Akiyoshi, Sayuri ^{[2
]}

Ueo, Hiroki ^{[1
]}

Nambara, Syo ^{[1
]}

Saito, Tomoko ^{[1
]}

Komatsu, Hisateru ^{[1
]}

Ueda, Masami ^{[1
]}

Hirata, Hidenari ^{[1
]}

Sakimura, Shotaro ^{[1
]}

Uchi, Ryutaro ^{[1
]}

Takano, Yuki ^{[1
]}

Iguchi, Tomohiro ^{[1
]}

Eguchi, Hidetoshi ^{[1
]}

Sugimachi, Keishi ^{[1
]}

Kijima, Yuko ^{[3
]}

Ueo, Hiroaki ^{[4
]}

Natsugoe, Shoji ^{[3
]}

Mimori, Koshi ^{[1
]}

机构：

[1] Kyushu Univ, Beppu Hosp, Dept Surg, Beppu, Oita 8740838, Japan

[2] Kyushu Canc Ctr, Natl Hosp Org, Minami Ku, Fukuoka, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Digest Surg Breast & Thyroid Surg, Sakuragaoka, Kagoshima, Japan

[4] Ueo Breast Surg Hosp, Haya, Oita, Japan

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 01期

基金：

日本学术振兴会;

关键词：

miR-15a; breast cancer; prognosis; MICRORNAS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: MiR-15a targets Cyclin El (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases. Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primal), tumors were measured by qRT-PCR assay. Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low rniR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04]. Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

引用

页码：123 / 127

页数：5

共 11 条

[1] [Anonymous], 2009, CANC BIOL THER
[2] MicroRNA signatures in human cancers
Calin, George A.
Croce, Carlo M.
[J]. NATURE REVIEWS CANCER, 2006, 6 (11) : 857 - 866
[3] Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
Goldhirsch, A.
Winer, E. P.
Coates, A. S.
Gelber, R. D.
Piccart-Gebhart, M.
Thuerlimann, B.
Senn, H. -J.
[J]. ANNALS OF ONCOLOGY, 2013, 24 (09) : 2206 - 2223
[4] MicroRNA gene expression deregulation in human breast cancer
Iorio, MV
Ferracin, M
Liu, CG
Veronese, A
Spizzo, R
Sabbioni, S
Magri, E
Pedriali, M
Fabbri, M
Campiglio, M
Ménard, S
Palazzo, JP
Rosenberg, A
Musiani, P
Volinia, S
Nenci, I
Calin, GA
Querzoli, P
Negrini, M
Croce, CM
[J]. CANCER RESEARCH, 2005, 65 (16) : 7065 - 7070
[5] Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: A case control study
Kodahl, Annette R.
Lyng, Maria B.
Binder, Harald
Cold, Soren
Gravgaard, Karina
Knoop, Ann S.
Ditzel, Henrik J.
[J]. MOLECULAR ONCOLOGY, 2014, 8 (05): : 874 - 883
[6] Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis
Liu, Xianpeng
Gu, Xin
Sun, Limin
Flowers, Ashley B.
Rademaker, Alfred W.
Zhou, Yiran
Kiyokawa, Hiroaki
[J]. BMC CANCER, 2014, 14
[7] MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer
Luo, Qifeng
Li, Xiaoyu
Li, Jia
Kong, Xiangjie
Zhang, Junfeng
Chen, Lei
Huang, Yixiang
Fang, Lin
[J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (04) : 1212 - 1218
[8] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients
Ota, Daisuke
Mimori, Koshi
Yokobori, Takehiko
Iwatsuki, Masaaki
Kataoka, Akemi
Masuda, Norikazu
Ishii, Hideshi
Ohno, Shinji
Mori, Masaki
[J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 38 (04) : 955 - 962
[9] Prognostic Significance of Progesterone Receptor-Positive Tumor Cells Within Immunohistochemically Defined Luminal A Breast Cancer
Prat, Aleix
Cheang, Maggie Chon U.
Martin, Miguel
Parker, Joel S.
Carrasco, Eva
Caballero, Rosalia
Tyldesley, Scott
Gelmon, Karen
Bernard, Philip S.
Nielsen, Torsten O.
Perou, Charles M.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (02) : 203 - 209
[10] microRNAs in breast cancer development and treatment
Serpico, Danila
Molino, Leonardo
Di Cosimo, Serena
[J]. CANCER TREATMENT REVIEWS, 2014, 40 (05) : 595 - 604

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