An efficient strategy for synthesis of new functionalized furo[3,2-c]pyridin-4(5H)-one derivatives under mild conditions

被引：4

作者：

Tao, Jiahao ^{[1
]}

Li, Chunmei ^{[1
,2
]}

Zhou, Kaini ^{[1
]}

Huan, Yongcan ^{[1
]}

Yuan, Yongjie ^{[1
]}

Liu, Ali ^{[1
]}

Zhang, Furen ^{[1
]}

Qi, Chenze ^{[1
]}

Shen, Zhenlu ^{[2
]}

机构：

[1] Shaoxing Univ, Sch Chem & Chem Engn, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 59卷 / 10期

基金：

中国国家自然科学基金;

关键词：

NF-KAPPA-B; IRIDIUM COMPLEXES; CASCADE REACTIONS; FACILE SYNTHESIS; NITROOLEFINS; FUROQUINOLINONES; PHOSPHORESCENT; REARRANGEMENT; CONSTRUCTION; CYCLIZATION;

D O I：

10.1002/jhet.4502

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we prepared a series of 5-alkyl-2,6-dimethyl-3-arylfuro[3,2-c]pyridin-4(5H)-one derivatives via the reaction of 1-substitued 4-hydroxy-6-methylpyridin-2(1H)-ones with various nitrostyrenes using triethylamine as catalyst. This strategy not only provided various new 5-alkyl-2,6-dimethyl-3-arylfuro[3,2-c]pyridin-4(5H)-ones, but also expanded the scope of application of active intermediate nitrostyrenes. Meanwhile, this method has the advantages of inexpensive and easily available starting materials, step economy, metal-free catalytic system, good to excellent yields and operational simplicity. A total of 22 heterocyclic compounds were obtained to exhibit a broad substrate scope of the strategy.

引用

页码：1742 / 1751

页数：10

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