A Genome-Wide Association Study of Novel Genetic Variants Associated With Anthropometric Traits in Koreans

被引：12

作者：

Cho, Hye-Won ^{[1
]}

Jin, Hyun-Seok ^{[2
]}

Eom, Yong-Bin ^{[1
,3
]}

机构：

[1] Soonchunhyang Univ, Grad Sch, Dept Med Sci, Asan, South Korea

[2] Hoseo Univ, Coll Life & Hlth Sci, Dept Biomed Lab Sci, Asan, South Korea

[3] Soonchunhyang Univ, Coll Med Sci, Dept Biomed Lab Sci, Asan, South Korea

来源：

FRONTIERS IN GENETICS | 2021年 / 12卷

基金：

新加坡国家研究基金会;

关键词：

genome-wide association study; Korean; East Asian; CUX2; rs7133285; eQTL; anthropometric traits; EAST ASIANS IDENTIFY; WAIST-HIP RATIO; LOCI; METAANALYSIS; HEIGHT; IDENTIFICATION;

D O I：

10.3389/fgene.2021.669215

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Most previous genome-wide association studies (GWAS) have identified genetic variants associated with anthropometric traits. However, most of the evidence were reported in European populations. Anthropometric traits such as height and body fat distribution are significantly affected by gender and genetic factors. Here we performed GWAS involving 64,193 Koreans to identify the genetic factors associated with anthropometric phenotypes including height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip ratio. We found nine novel single-nucleotide polymorphisms (SNPs) and 59 independent genetic signals in genomic regions that were reported previously. Of the 19 SNPs reported previously, eight genetic variants at RP11-513I15.6 and one genetic variant at the RP11-977G19.10 region and six Asian-specific genetic variants were newly found. We compared our findings with those of previous studies in other populations. Five overlapping genetic regions (PAN2, ANKRD52, RNF41, HGMA1, and C6orf106) had been reported previously but none of the SNPs were independently identified in the current study. Seven of the nine newly found novel loci associated with height in women revealed a statistically significant skeletal expression of quantitative trait loci. Our study provides additional insight into the genetic effects of anthropometric phenotypes in East Asians.

引用

页数：9

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