Molecular biology of pancreatic adenocarcinoma

被引：1
作者：
Rueckert, F. [1 ]
Aust, D. [2 ]
Pilarsky, C. [1 ]
Gruetzmann, R. [1 ]
机构：
[1] Tech Univ Dresden, Univ Carl Gustav Carus, Klin & Poliklin Viszeral Thorax & Gefasschirurg, D-01307 Dresden, Germany
[2] Tech Univ Dresden, Univ Carl Gustav Carus, Inst Pathol, D-01307 Dresden, Germany
来源：
ONKOLOGE | 2010年 / 16卷 / 06期
关键词：
Pancreatic carcinoma; Molecular biology; Mutations; Signalling pathway; Precursor lesion; DUCTAL ADENOCARCINOMA; CLINICAL-IMPLICATIONS; CARCINOMA CELLS; CANCER; GROWTH; GENE; P16; CARCINOGENESIS; PATHOGENESIS; PRECURSORS;
D O I：
10.1007/s00761-010-1846-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma contributes to over 90% of pancreatic malignancies and each year 6,050 people develop pancreatic cancer in Germany. At present surgery is the only therapy with curative intention. Conventional oncological therapies, such as radiation therapy, chemotherapy or combined therapy could not satisfactorily prolong survival in advanced pancreatic carcinoma. In addition to continuous advances in conventional therapy, we see a development in basic research which might contribute to future new therapeutic strategies. The present review will focus on these new insights into the molecular biology of pancreatic ductal adenocarcinoma.
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页码：5 / +
页数：8
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