Compartmentalization of Sphingolipid metabolism: Implications for signaling and therapy

被引：26
作者：
Canals, Daniel [1 ,2 ]
Clarke, Christopher J. [1 ,2 ]
机构：
[1] SUNY Stony Brook, Dept Med, 100 Nicolls Rd, Stony Brook, NY 11776 USA
[2] SUNY Stony Brook, Canc Ctr, 100 Nicolls Rd, Stony Brook, NY 11776 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2022年 / 232卷
基金：
美国国家卫生研究院;
关键词：
SPHINGOMYELIN-SPECIFIC TOXIN; CERAMIDE TRANSPORT PROTEIN; ENDOPLASMIC-RETICULUM; GOLGI-APPARATUS; PLASMA-MEMBRANE; NEUTRAL SPHINGOMYELINASE-2; SPHINGOSINE; 1-PHOSPHATE; NONVESICULAR TRAFFICKING; SUBCELLULAR-LOCALIZATION; QUANTITATIVE-ANALYSIS;
D O I：
10.1016/j.pharmthera.2021.108005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Sphingolipids (SLs) are a family of bioactive lipids implicated in a variety of cellular processes, and whose levels are controlled by an interlinked network of enzymes. While the spatial distribution of SL metabolism throughout the cell has been understood for some time, the implications of this for SL signaling and biological outcomes have only recently begun to be fully explored. In this review, we outline the compartmentalization of SL metabolism and describe advances in tools for investigating and probing compartment-specific SL functions. We also briefly discuss the implications of SL compartmentalization for cell signaling and therapeutic approaches to targeting the SL network. (C) 2021 Elsevier Inc. All rights reserved.
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页数：10
相关论文
共 148 条
[1]   Sphingolipid lysosomal storage diseases: from bench to bedside [J].
Abed Rabbo, Muna ;
Khodour, Yara ;
Kaguni, Laurie S. ;
Stiban, Johnny .
LIPIDS IN HEALTH AND DISEASE, 2021, 20 (01)
[2]   Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics [J].
Adada, Mohamad ;
Canals, Daniel ;
Hannun, Yusuf A. ;
Obeid, Lina M. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2014, 1841 (05) :727-737
[3]   Sphingosine-1-phosphate receptor 2 [J].
Adada, Mohamad ;
Canals, Daniel ;
Hannun, Yusuf A. ;
Obeid, Lina M. .
FEBS JOURNAL, 2013, 280 (24) :6354-6366
[4]   Sphingomyelin synthase in rat liver nuclear membrane and chromatin [J].
Albi, E ;
Magni, MV .
FEBS LETTERS, 1999, 460 (02) :369-372
[5]   Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight [J].
Albi, Elisabetta ;
Cataldi, Samuela ;
Villani, Maristella ;
Perrella, Giuseppina .
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2009,
[6]   Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 [J].
Alvarez, Sergio E. ;
Harikumar, Kuzhuvelil B. ;
Hait, Nitai C. ;
Allegood, Jeremy ;
Strub, Graham M. ;
Kim, Eugene Y. ;
Maceyka, Michael ;
Jiang, Hualiang ;
Luo, Cheng ;
Kordula, Tomasz ;
Milstien, Sheldon ;
Spiegel, Sarah .
NATURE, 2010, 465 (7301) :1084-U149
[7]   Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumor necrosis factor [J].
Andrieu, N ;
Salvayre, R ;
Levade, T .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 236 (02) :738-745
[8]   The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases [J].
Ardail, D ;
Popa, I ;
Bodennec, J ;
Louisot, P ;
Schmitt, D ;
Portoukalian, J .
BIOCHEMICAL JOURNAL, 2003, 371 (03) :1013-1019
[9]   Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria [J].
Ardail, D ;
Popa, I ;
Alcantara, K ;
Pons, A ;
Zanetta, JP ;
Louisot, P ;
Thomas, L ;
Portoukalian, J .
FEBS LETTERS, 2001, 488 (03) :160-164
[10]   Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase [J].
Augé, N ;
Nikolova-Karakashian, M ;
Carpentier, S ;
Parthasarathy, S ;
Négre-Salvayre, A ;
Salvayre, R ;
Merrill, AH ;
Levade, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (31) :21533-21538
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