Salivaomics for Oral Cancer Detection: An Insight

被引:5
作者
Chundru, V. Naga Sirisha [1 ]
Nirmal, Ramadas Madhavan [4 ]
Srikanth, B. [2 ]
Bojji, Manasa [1 ]
Midhun, Namburi [5 ]
Lakshmi, B. Jaya [3 ]
机构
[1] Tirumala Inst Dent Sci & Res Ctr, Dept Oral & Maxillofacial Pathol, Malla Reddy Dent Coll Women, Nizamabad, Telangana, India
[2] Tirumala Inst Dent Sci & Res Ctr, Dept Dent Surg, MNJ Inst Oncol & Reg Canc Ctr, Nizamabad, Telangana, India
[3] Tirumala Inst Dent Sci & Res Ctr, Dept Oral Med & Radiol, Nizamabad, Telangana, India
[4] Rajah Muthiah Dent Coll & Hosp, Dept Oral & Maxillofacial Pathol, Chidambaram, Tamil Nadu, India
[5] CKS Theja Inst Dent Sci, Dept Oral & Maxillofacial Pathol, Tirupati, Andhra Pradesh, India
来源
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2021年 / 13卷 / 05期
关键词
Biomarkers; molecular signatures; oral cancer; saliva; salivaomics; SALIVARY BIOMARKERS; DIAGNOSTICS; P53;
D O I
10.4103/jpbs.JPBS_529_20
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Early detection is very crucial for successful management of oral cancer or any disease as such. Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of malignancy of oral cavity. In the field of cancer research, there is always an ongoing quest for newer methods to lower the morbidity and mortality associated with OSCC. Saliva, a readily available noninvasive biofluid with constant contact with oral cancer lesion, offers an appealing alternative to serum and tissue testing. This review throws light on incorporation of newer technologies for harnessing the saliva to its fullest potential with increased specificity and sensitivity toward identification of cancer-specific molecular signatures for the development of point-of-care applications that could be used at the clinical setting.
引用
收藏
页码:52 / 56
页数:5
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