Probing the mechanism of the petasis olefination reaction by atmospheric pressure chemical ionization mass and tandem mass spectrometry

被引：54

作者：

Meurer, EC ^{[1
]}

Santos, LS ^{[1
]}

Pilli, RA ^{[1
]}

Eberlin, MN ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP, Brazil

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 09期

关键词：

D O I：

10.1021/ol027439b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic Atmospheric pressure chemical ionization mass (APCI-MS) and tandem mass spectrometry (APCI-MS/MS) is used to probe the mechanism of the Petasis olefination reaction. Oxatitanacycle intermediates 4 were transferred from solution to the gas phase, detected as 4H(+) by APCI-MS with characteristic Ti-isotopic patterns, and structurally characterized by APCI-MS/MS. Detection of 4H(+), which upon collision activation dissociates to both 3H(+) and Cp2TiOH+, fully supports the Hughes mechanism as depicted above.

引用

页码：1391 / 1394

页数：4

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