Base-Promoted Ecofriendly Synthesis of Trisubstituted Pyrazoles from α,β-Alkynyl N-Tosylhydrazones under Metal- and Solvent-Free Conditions

被引：17

作者：

Li, Ning ^{[1
]}

Li, Baoguo ^{[1
]}

Chen, Shufeng ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

来源：

SYNLETT | 2016年 / 27卷 / 10期

基金：

中国国家自然科学基金;

关键词：

hydrazones; green chemistry; pyrazoles; cyclizations; ONE-POT SYNTHESIS; FUNCTIONALIZED PYRAZOLES; DERIVATIVES; INHIBITORS; HYDRAZONES; HETEROCYCLES; CYCLIZATION; WATER; DISCOVERY; ARYLATION;

D O I：

10.1055/s-0035-1561853

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and green method is described for the synthesis of trisubstituted pyrazoles from ,-alkynyl N-tosylhydrazones under metal- and solvent-free conditions. Notably, only diisopropylamine is required as a promoter, and the reaction can be easily performed at room temperature and on a gram scale.

引用

页码：1597 / 1601

页数：5

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