The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism

被引：105

作者：

Song, Moon-Young ^{[1
,2
]}

Lee, Da-Young ^{[1
,2
]}

Chun, Kyung-Soo ^{[3
]}

Kim, Eun-Hee ^{[1
,2
]}

机构：

[1] CHA Univ, Coll Pharm, Seongnam 13488, South Korea

[2] CHA Univ, Inst Pharmaceut Sci, Seongnam 13488, South Korea

[3] Keimyung Univ, Coll Pharm, Daegu 42601, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

NRF2; KEAP1; cancer metabolism; metabolic reprogramming; TRANSCRIPTION FACTOR NRF2; OXIDATIVE STRESS-RESPONSE; ANTIOXIDANT RESPONSE; AMINO-ACID; MITOCHONDRIAL BIOGENESIS; NF-E2-RELATED FACTOR-2; ADAPTIVE RESPONSE; TRANSPORTER GENE; CELL METABOLISM; DOWN-REGULATION;

D O I：

10.3390/ijms22094376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also called Nfe2l2) and its cytoplasmic repressor, Kelch-like ECH-associated protein 1 (KEAP1), are major regulators of redox homeostasis controlling a multiple of genes for detoxification and cytoprotective enzymes. The NRF2/KEAP1 pathway is a fundamental signaling cascade responsible for the resistance of metabolic, oxidative stress, inflammation, and anticancer effects. Interestingly, a recent accumulation of evidence has indicated that NRF2 exhibits an aberrant activation in cancer. Evidence has shown that the NRF2/KEAP1 signaling pathway is associated with the proliferation of cancer cells and tumerigenesis through metabolic reprogramming. In this review, we provide an overview of the regulatory molecular mechanism of the NRF2/KEAP1 pathway against metabolic reprogramming in cancer, suggesting that the regulation of NRF2/KEAP1 axis might approach as a novel therapeutic strategy for cancers.

引用

页数：16

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