Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis vivenini

被引：52
作者：
Keiser, Jennifer [1 ]
Xiao Shu-Hua
Chollet, Jacques
Tanner, Marcel
Utzinger, Jurg
机构：
[1] Swiss Trop Inst, CH-4002 Basel, Switzerland
[2] Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200025, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 03期
关键词：
D O I：
10.1128/AAC.01366-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
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收藏
页码：1096 / 1098
页数：3
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