AllergoOncology - the impact of allergy in oncology: EAACI position paper

被引:76
作者
Jensen-Jarolim, E. [1 ,2 ]
Bax, H. J. [3 ,4 ]
Bianchini, R. [1 ]
Capron, M. [5 ]
Corrigan, C. [6 ,7 ]
Castells, M. [8 ]
Dombrowicz, D. [9 ]
Daniels-Wells, T. R. [10 ]
Fazekas, J. [1 ,2 ]
Fiebiger, E. [11 ]
Gatault, S. [5 ]
Gould, H. J. [6 ,7 ,12 ,13 ,14 ]
Janda, J. [15 ]
Josephs, D. H. [3 ,4 ]
Karagiannis, P. [3 ,13 ,14 ]
Levi-Schaffer, F. [16 ]
Meshcheryakova, A. [2 ]
Mechtcheriakova, D. [2 ]
Mekori, Y. [17 ]
Mungenast, F. [2 ]
Nigro, E. A. [18 ]
Penichet, M. L. [10 ,19 ,20 ]
Redegeld, F. [21 ]
Saul, L. [3 ,4 ]
Singer, J. [2 ]
Spicer, J. F. [4 ,13 ,14 ]
Siccardi, A. G. [18 ]
Spillner, E. [22 ]
Turner, M. C. [23 ,24 ,25 ,26 ]
Untersmayr, E. [2 ]
Vangelista, L. [27 ]
Karagiannis, S. N. [3 ,13 ,14 ]
机构
[1] Med Univ Vienna, Univ Vet Med Vienna, Interuniv Messerli Res Inst, Vienna, Austria
[2] Med Univ Vienna, Inst Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Spitalgasse 23, A-1090 Vienna, Austria
[3] Kings Coll London, St Johns Inst Dermatol, Div Genet & Mol Med, Fac Life Sci & Med, London, England
[4] Guys Hosp, Kings Coll London, Fac Life Sci & Med, Div Canc Studies, London, England
[5] Univ Lille 2, INSERM, CHRU Lille, LIRIC,Unit Mixte Rech 995, Lille, France
[6] MRC, Div Asthma Allergy & Lung Biol, London, England
[7] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London, England
[8] Harvard Med Sch, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Dept Med, Boston, MA USA
[9] Univ Lille, INSERM,U1011, CHU Lille,Recepteurs Nucl Malad Cardiovasc & Diab, European Genom Inst Diabet,Inst Pasteur Lille, Lille, France
[10] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Surg Oncol, Los Angeles, CA 90095 USA
[11] Childrens Univ Hosp Boston, Div Gastroenterol Hepatol & Nutr Res, Dept Med Res, Boston, MA USA
[12] Kings Coll London, Randall Div Cell & Mol Biophys, London, England
[13] Guys & St Thomas Hosp, NIHR Biomed Res Ctr, London, England
[14] Guys Hosp, Kings Coll London, London, England
[15] Acad Sci Czech Republ, Inst Anim Physiol & Genet, Ctr Pigmod, Libechov, Czech Republic
[16] Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, Pharmacol & Expt Therapeut Unit,Fac Med, Jerusalem, Israel
[17] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[18] IRCCS, San Raffaele Sci Inst, Milan, Italy
[19] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[20] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
[21] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, Fac Sci, Utrecht, Netherlands
[22] Aarhus Univ, Dept Engn, Immunol Engn, Aarhus, Denmark
[23] Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
[24] Univ Pompeu Fabra, Barcelona, Spain
[25] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[26] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada
[27] Nazarbayev Univ, Dept Biomed Sci, Sch Med, Astana, Kazakhstan
基金
英国医学研究理事会; 以色列科学基金会; 奥地利科学基金会; 加拿大健康研究院;
关键词
AllergoOncology; allergy; atopy; cancer; tumor; IgE; IgG4; chemotherapeutic; biologics; desensitization; clinical oncology; inflammation; FC-EPSILON-RI; ANTIBODY-DEPENDENT CYTOTOXICITY; MEDIATED TUMORICIDAL ACTIVITY; MAST-CELL DEGRANULATION; IMMUNOGLOBULIN-E LEVELS; IGE-ANTIBODY; PROSTATE-CANCER; HYPERSENSITIVITY REACTIONS; PANCREATIC-CANCER; BREAST-CANCER;
D O I
10.1111/all.13119
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.
引用
收藏
页码:866 / 887
页数:22
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