Hydrolysis of polypeptide esters with tetrabutylammonium hydroxide

被引：25

作者：

Abdel-Magid, AF ^{[1
]}

Cohen, JH ^{[1
]}

Maryanoff, CA ^{[1
]}

Shah, RD ^{[1
]}

Villani, FJ ^{[1
]}

Zhang, F ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, New Prod Res, Dept Chem Dev, Spring House, PA 19477 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00511-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrabutylammonium hydroxide is effective in hydrolysis of polypeptide esters to the corresponding acids with minimum racemization of the stereogenic centers at the alpha-positions. It is especially effective in hydrolysis of non-polar polypeptide esters that are insoluble in most common solvents. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3391 / 3394

页数：4

共 14 条

[1]

*ACS, 1997, 213 ACS NAT M SAN FR

[2]

BARTLETT PA, 1970, TETRAHEDRON LETT, P4459

[3]

BOS ME, 1995, ENCY REAGENTS ORGANI, V7, P4733

[4] SIMPLIFIED PREPARATION OF L-ALPHA-GLYCERYL PHOSPHORYL CHOLINE [J].

BROCKERHOFF, H ;

YURKOWSKI, M .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1965, 43 (10) :1777-+

[5]

CHANG FC, 1964, TETRAHEDRON LETT, P2969

[6] PULMONARY SURFACTANT PROTEIN-B (SP-B) - STRUCTURE-FUNCTION-RELATIONSHIPS [J].

COCHRANE, CG ;

REVAK, SD .

SCIENCE, 1991, 254 (5031) :566-568

[7] SYNTHESIS AND CHARACTERIZATION OF SOME POLYURETHANE IONOMERS [J].

EGBOH, HS ;

GHAFFAR, A ;

GEORGE, MH ;

BARRIE, JA ;

WALSH, DJ .

POLYMER, 1982, 23 (08) :1167-1171

[8] NOTIZ UBER DIE SELEKTIVITAT DER SPALTUNG VON CARBONSAURE-METHYLESTERN MIT LITHIUMJODID [J].

ELSINGER, F ;

SCHREIBER, J ;

ESCHENMOSER, A .

HELVETICA CHIMICA ACTA, 1960, 43 (01) :113-118

[9] CLEAVAGE OF ESTERS USING CARBONATES AND BICARBONATES OF ALKALI-METALS - SYNTHESIS OF THYMOPENTIN [J].

KAESTLE, KL ;

ANWER, MK ;

AUDHYA, TK ;

GOLDSTEIN, G .

TETRAHEDRON LETTERS, 1991, 32 (03) :327-330

[10]

LIOTTA D, 1977, TETRAHEDRON LETT, P4365

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