Chemical composition and cytotoxic activity of the leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica

被引：35

作者：

Cole, Ramona A.

Bansal, Anita

Moriarity, Debra M.

Haber, William A.

Setzer, William N. ^{[1
]}

机构：

[1] Univ Alabama, Dept Chem, Huntsville, AL 35899 USA

[2] Univ Alabama, Dept Biol Sci, Huntsville, AL 35899 USA

[3] Missouri Bot Garden, St Louis, MO 63166 USA

来源：

JOURNAL OF NATURAL MEDICINES | 2007年 / 61卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Eugenia zuchowskiae; sssential oil; chemical composition; cytotoxicity;

D O I：

10.1007/s11418-007-0155-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC-MS. The principal constituents of E. zuchowskiae leaf oil were alpha-pinene (28.3%), beta-caryophyllene (13.2%), alpha-humulene (13.1%), and alpha-copaene (8.1%). The leaf essential oil of E. zuchowskiae showed pronounced in-vitro cytotoxic activity against MCF-7, MDA-MB-468, and UACC-257 human tumor cell lines. The major components showed cytotoxic activities comparable to doxorubicin (LC50 14-70 mu g/ml).

引用

页码：414 / 417

页数：4

共 22 条

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