The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses

被引：35

作者：

Cui, Jun ^{[1
,2
]}

Jin, Shouheng ^{[1
,2
]}

Wang, Rong-Fu ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, Key Lab Gene Engn, Minist Educ,State Key Lab Biocontrol, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China

[3] Houston Methodist Res Inst, Ctr Inflammat & Epigenet, Houston, TX USA

来源：

AUTOPHAGY | 2016年 / 12卷 / 07期

关键词：

autophagy; BECN1; crosstalk; type I interferon; ubiquitination; USP19;

D O I：

10.1080/15548627.2016.1173801

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy/autophagy is a conserved intracellular degradation system that traffics substrates including protein aggregates, defunct or disused organelles and invading pathogens to lysosomes via double-membrane vesicles called autophagosomes. BECN1/Beclin 1 functions as a key protein in autophagy initiation and progression; however, the role of BECN1 in innate immunity has not been fully investigated. Recently, we have found that USP19 affects the ubiquitination of BECN1, hence promoting the formation of autophagosomes and inhibiting DDX58/RIG-I-mediated type I interferon signaling.

引用

页码：1210 / 1211

页数：2