Targeting neoantigens for cancer immunotherapy

被引:32
|
作者
Zhao, Xuan [1 ,2 ,3 ]
Pan, Xiaoxin [4 ]
Wang, Yi [4 ]
Zhang, Yi [1 ,2 ,3 ,5 ,6 ]
机构
[1] Zhengzhou Univ, Biotherapy Ctr, Zhengzhou 450052, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Ctr Canc, Zhengzhou 450052, Peoples R China
[3] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatmen, Zhengzhou 450052, Peoples R China
[4] Shenzhen Neocura Biotechnol Corp, Shenzhen 518055, Peoples R China
[5] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450052, Peoples R China
[6] Henan Key Lab Tumor Immunol & Biotherapy, Zhengzhou 450052, Peoples R China
基金
中国国家自然科学基金;
关键词
Neoantigen vaccine; Cancer immunotherapy; Precision medicine; PEPTIDE VACCINE; TESTIS ANTIGEN; THERAPY; FUTURE; TRIAL; LYMPHOCYTES; MELANOMA; IMMUNITY; CELLS;
D O I
10.1186/s40364-021-00315-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Neoantigens, a type of tumor-specific antigens derived from non-synonymous mutations, have recently been characterized as attractive targets for cancer immunotherapy. Owing to the development of next-generation sequencing and utilization of machine-learning algorithms, it has become feasible to computationally predict neoantigens by depicting genetic alterations, aberrant post-transcriptional mRNA processing and abnormal mRNA translation events within tumor tissues. Consequently, neoantigen-based therapies such as cancer vaccines have been widely tested in clinical trials and have demonstrated promising safety and efficacy, opening a new era for cancer immunotherapy. We systematically summarize recent advances in the identification of both personalized and public neoantigens, neoantigen formulations and neoantigen-based clinical trials in this review. Moreover, we discuss future techniques and strategies for neoantigen-based cancer treatment either as a monotherapy or as a combination therapy with radiotherapy, chemotherapy or immune checkpoint inhibitors.
引用
收藏
页数:12
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