The DRAGO gamma camera

被引:11
作者
Fiorini, C. [1 ,2 ]
Gola, A. [1 ,2 ]
Peloso, R. [1 ,2 ]
Longoni, A. [1 ,2 ]
Lechner, P. [3 ,4 ]
Soltau, H. [3 ,4 ]
Strueder, L. [5 ]
Ottobrini, L. [6 ,7 ]
Martelli, C. [6 ,7 ]
Lui, R. [6 ,7 ]
Madaschi, L. [8 ]
Belloli, S. [9 ]
机构
[1] Politecn Milan, Dipartimento Elettron & Informaz, I-20133 Milan, Italy
[2] Ist Nazl Fis Nucl, Sez Milano, I-20133 Milan, Italy
[3] PNSensor GmbH, D-80803 Munich, Germany
[4] PNDetector GmbH, D-80803 Munich, Germany
[5] Max Planck Inst Halbleiterlabor, D-81739 Munich, Germany
[6] Univ Milan, Dept Biomed Sci & Technol, I-20133 Milan, Italy
[7] IMAGO, Ctr Mol & Cellular Imaging, Milan, Italy
[8] Univ Milan, Dept Med Surg & Dent, I-20142 Milan, Italy
[9] Ist Sci Osped San Raffale, CNR, IBFM, I-20132 Milan, Italy
关键词
cameras; gamma-ray detection; image sensors; readout electronics; scintillation; X-RAY; CANCER-IMMUNOTHERAPY; SCINTILLATION CAMERA; DENDRITIC CELLS; SPECTROSCOPY; READOUT; SYSTEM; ARRAY; RESOLUTION; DETECTORS;
D O I
10.1063/1.3378686
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm(2), coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated Co-57 source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45 degrees with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.
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页数:7
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