Chromatin modulation of glucocorticoid and progesterone receptor activity

被引:14
作者
Archer, TK [1 ]
Deroo, BJ
Fryer, CJ
机构
[1] Univ Western Ontario, London Reg Canc Ctr, Dept Obstet & Gynecol, London, ON N6A 4L6, Canada
[2] Univ Western Ontario, London Reg Canc Ctr, Dept Biochem, London, ON N6A 4L6, Canada
[3] Univ Western Ontario, London Reg Canc Ctr, Dept Oncol, London, ON N6A 4L6, Canada
基金
加拿大自然科学与工程研究理事会; 英国医学研究理事会;
关键词
D O I
10.1016/S1043-2760(97)00159-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Steroid hormone receptors are ligand-activated transcription factors that enhance or repress gene expression. They act by binding to target sites within the promoters of genes assembled as chromatin, Chromatin structure is modified in response to steroid hormones and represents a critical step in steroid receptor signaling. Recent experiments demonstrate that the progesterone and glucocorticoid receptors are differentially influenced by this arrangement of DNA and histones. One of the most important developments in the steroid hormone receptor field has been the identification of coactivators and cointegrators, some of which ave histone acetyltransferases, These proteins appear to play an important role in mediating ligand activation of transcription, although their exact role on chromatin templates is undefined. (C) 1998, Elsevier Science Inc.
引用
收藏
页码:384 / 390
页数:7
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