From Allergen Genes to Allergy Vaccines

被引：172

作者：

Valenta, Rudolf ^{[1
,2
]}

Ferreira, Fatima ^{[4
]}

Focke-Tejkl, Margarete ^{[1
,2
]}

Linhart, Birgit ^{[2
]}

Niederberger, Verena ^{[3
]}

Swoboda, Ines ^{[1
,2
]}

Vrtala, Susanne ^{[2
]}

机构：

[1] Med Univ Vienna, Christian Doppler Lab Allergy Res, A-1090 Vienna, Austria

[2] Med Univ Vienna, Ctr Physiol & Pathophysiol, Dept Pathophysiol, Div Immunopathol, A-1090 Vienna, Austria

[3] Med Univ Vienna, Dept Otorhinolaryngol, A-1090 Vienna, Austria

[4] Salzburg Univ, Christian Doppler Lab Allergy Diag & Therapy, A-5020 Salzburg, Austria

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 | 2010年 / 28卷

基金：

奥地利科学基金会;

关键词：

allergy; recombinant allergen; specific immunotherapy; IgE; T cell; peptide; diagnosis; BIRCH POLLEN ALLERGEN; DUST MITE ALLERGEN; T-CELL EPITOPE; BET V 1; SHORT RAGWEED ALLERGEN; BASOPHIL HISTAMINE-RELEASE; IGG MONOCLONAL-ANTIBODIES; IMMUNOGLOBULIN-E RESPONSE; FC-EPSILON-RI; DER-P-I;

D O I：

10.1146/annurev-immunol-030409-101218

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgE-mediated allergy is a hypersensitivity disease affecting more than 25% of the population. The structures of the most common allergens have been revealed through molecular cloning technology in the past two decades. On the basis of this knowledge of the sequences and three-dimensional structures of culprit allergens, investigators can now analyze the immune recognition of allergens and the mechanisms of allergic inflammation in allergic patients. Allergy vaccines have been constructed that are able to selectively target the aberrant immune responses in allergic patients via different pathways of the immune system. Here we review various types of allergy vaccines that have been developed based on allergen structures, results from their clinical application in allergic patients, and future strategies for allergen-specific immunotherapy and allergy prophylaxis.

引用

页码：211 / 241

页数：31

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