Posterior Left Atrial Adipose Tissue Attenuation Assessed by Computed Tomography and Recurrence of Atrial Fibrillation After Catheter Ablation

被引：47

作者：

El Mahdiui, Mohammed ^{[1
]}

Simon, Judit ^{[4
]}

Smit, Jeff M. ^{[1
]}

Kuneman, Jurrien H. ^{[1
]}

van Rosendael, Alexander R. ^{[1
]}

Steyerberg, Ewout W. ^{[2
]}

van der Geest, Rob J. ^{[3
]}

Szaraz, Lili ^{[4
]}

Herczeg, Szilvia ^{[4
]}

Szegedi, Nandor ^{[4
]}

Geller, Laszlo ^{[4
]}

Delgado, Victoria ^{[1
]}

Merkely, Bela ^{[4
]}

Bax, Jeroen J. ^{[1
]}

Maurovich-Horvat, Pal ^{[4
,5
]}

机构：

[1] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands

[2] Leiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, Netherlands

[3] Leiden Univ, Div Image Proc, Med Ctr, Leiden, Netherlands

[4] Semmelweis Univ, MTA SE Cardiovasc Imaging Res Grp, Heart & Vasc Ctr, Budapest, Hungary

[5] Semmelweis Univ, Med Imaging Ctr, Dept Radiol, 2 Koranyi Sandoru, H-1083 Budapest, Hungary

来源：

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY | 2021年 / 14卷 / 04期

关键词：

atrial fibrillation; atrial fibrillation recurrence; catheter ablation; computed tomography; epicardial fat; C-REACTIVE PROTEIN; INDEPENDENT PREDICTOR; ASSOCIATION; VOLUMES; RISK;

D O I：

10.1161/CIRCEP.120.009135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Atrial fibrillation (AF) recurrence following catheter ablation remains high. Recent studies have shown a relation between epicardial adipose tissue and AF. epicardial adipose tissue secretes several proinflammatory and anti-inflammatory adipokines that directly interact with the adjacent myocardium. The aim of the current study was to evaluate whether posterior left atrial (LA) adipose tissue attenuation, as marker of inflammation, is related to AF recurrences after catheter ablation. METHODS: Consecutive patients with symptomatic AF referred for first AF catheter ablation who underwent computed tomography were included. The total epicardial adipose tissue and posterior LA adipose tissue were manually traced and adipose tissue was automatically recognized as tissue with Hounsfield units (HU) between -195 and -45. The attenuation value of the posterior LA adipose tissue was assessed, and the population was divided according to the mean HU value (-96.4 HU). RESULTS: In total, 460 patients (66% male, age 61 +/- 10 years) were included in the analysis. After a median follow-up of 18 months (interquartile range, 6-32), 168 (37%) patients had AF recurrence. Patients with higher attenuation (>=-96.4 HU) of the posterior LA adipose tissue showed higher AF recurrence rates compared with patients with lower attenuation (P=0.046). Univariate analysis showed an association between AF recurrence and higher posterior LA adipose tissue attenuation (>=-96.4 HU; P<0.05). On multivariable analysis, posterior LA adipose tissue attenuation (hazard ratio, 1.26 [95% CI, 0.90-1.76]; P=0.181) remained a promising predictor of AF recurrence following catheter ablation. CONCLUSIONS: Posterior LA adipose tissue attenuation is a promising predictor of AF recurrence in patients who undergo catheter ablation. Higher adipose tissue attenuation might signal increased local inflammation and serve as an imaging biomarker of increased risk of AF recurrence. GRAPHIC ABSTRACT: A is available for this article.

引用

页码：404 / 411

页数：8

共 34 条

[1] Association of fibrotic remodeling and cytokines/chemokines content in epicardial adipose tissue with atrial myocardial fibrosis in patients with atrial fibrillation [J].

Abe, Ichitaro ;

Teshima, Yasushi ;

Kondo, Hidekazu ;

Kaku, Haruka ;

Kira, Shintaro ;

Ikebe, Yuki ;

Saito, Shotaro ;

Fukui, Akira ;

Shinohara, Tetsuji ;

Yufu, Kunio ;

Nakagawa, Mikiko ;

Hijiya, Naoki ;

Moriyama, Masatsugu ;

Shimada, Tatsuo ;

Miyamoto, Shinji ;

Takahashi, Naohiko .

HEART RHYTHM, 2018, 15 (11) :1717-1727

[2] Left Atrial Epicardial Adiposity and Atrial Fibrillation [J].

Batal, Omar ;

Schoenhagen, Paul ;

Shao, Mingyuan ;

Ayyad, Ala Eddin ;

Van Wagoner, David R. ;

Halliburton, Sandra S. ;

Tchou, Patrick J. ;

Chung, Mina K. .

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2010, 3 (03) :230-236

[3] The Impact of Age on 5-Year Outcomes After Atrial Fibrillation Catheter Ablation [J].

Bunch, T. Jared ;

May, Heidi T. ;

Bair, Tami L. ;

Jacobs, Victoria ;

Crandall, Brian G. ;

Cutler, Michael ;

Weiss, J. Peter ;

Mallender, Charles ;

Osborn, Jeffrey S. ;

Anderson, Jeffrey L. ;

Day, John D. .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2016, 27 (02) :141-146

[4] Success of Ablation for Atrial Fibrillation in Isolated Left Ventricular Diastolic Dysfunction A Comparison to Systolic Dysfunction and Normal Ventricular Function [J].

Cha, Yong-Mei ;

Wokhlu, Anita ;

Asirvatham, Samuel J. ;

Shen, Win-Kuang ;

Friedman, Paul A. ;

Munger, Thomas M. ;

Oh, Jae K. ;

Monahan, Kristi H. ;

Haroldson, Janis M. ;

Hodge, David O. ;

Herges, Regina M. ;

Hammill, Stephen C. ;

Packer, Douglas L. .

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2011, 4 (05) :724-732

[5] C-reactive protein elevation in patients with atrial arrhythmias - Inflammatory mechanisms and persistence of atrial fibrillation [J].

Chung, MK ;

Martin, DO ;

Sprecher, D ;

Wazni, O ;

Kanderian, A ;

Carnes, CA ;

Bauer, JA ;

Tchou, PJ ;

Niebauer, MJ ;

Natale, A ;

Van Wagoner, DR .

CIRCULATION, 2001, 104 (24) :2886-2891

[6] Periatrial Fat Quality Predicts Atrial Fibrillation Ablation Outcome [J].

Ciuffo, Luisa ;

Hieu Nguyen ;

Marques, Mateus Diniz ;

Aronis, Konstantinos N. ;

Sivasambu, Bhradeev ;

de Vasconcelos, Henrique D. ;

Tao, Susumu ;

Spragg, David D. ;

Marine, Joseph E. ;

Berger, Ronald D. ;

Lima, Joao A. C. ;

Calkins, Hugh ;

Ashikaga, Hiroshi .

CIRCULATION-CARDIOVASCULAR IMAGING, 2019, 12 (06) :e008764

[7] PulmOnary vein isolation With vs. without continued antiarrhythmic Drug trEatment in subjects with Recurrent Atrial Fibrillation (POWDER AF): results from a multicentre randomized trial [J].

Duytschaever, Mattias ;

Demolder, Anthony ;

Phlips, Thomas ;

Sarkozy, Andrea ;

El Haddad, Mitad ;

Taghji, Philippe ;

Knecht, Sebastien ;

Tavernier, Rene ;

Vandekerckhove, Yves ;

De Potter, Tom .

EUROPEAN HEART JOURNAL, 2018, 39 (16) :1429-1437

[8] Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index [J].

Elnabawi, Youssef A. ;

Oikonomou, Evangelos K. ;

Dey, Amit K. ;

Mancio, Jennifer ;

Rodante, Justin A. ;

Aksentijevich, Milena ;

Choi, Harry ;

Keel, Andrew ;

Erb-Alvarez, Julie ;

Teague, Heather L. ;

Joshi, Aditya A. ;

Playford, Martin P. ;

Lockshin, Benjamin ;

Choi, Andrew D. ;

Gelfand, Joel M. ;

Chen, Marcus Y. ;

Bluemke, David A. ;

Shirodaria, Cheerag ;

Antoniades, Charalambos ;

Mehta, Nehal N. .

JAMA CARDIOLOGY, 2019, 4 (09) :885-891

[9] Histological substrate of atrial biopsies in patients with lone atrial fibrillation [J].

Frustaci, A ;

Chimenti, C ;

Bellocci, F ;

Morgante, E ;

Russo, MA ;

Maseri, A .

CIRCULATION, 1997, 96 (04) :1180-1184

[10] Pericoronary Adipose Tissue Computed Tomography Attenuation and High-Risk Plaque characteristics in Acute Coronary Syndrome Compared With Stable Coronary Artery Disease [J].

Goeller, Markus ;

Achenbach, Stephan ;

Cadet, Sebastien ;

Kwan, Alan C. ;

Commandeur, Frederic ;

Slomka, Piotr J. ;

Gransar, Heidi ;

Albrecht, Moritz H. ;

Tamarappoo, Balaji K. ;

Berman, Daniel S. ;

Marwan, Mohamed ;

Dey, Damini .

JAMA CARDIOLOGY, 2018, 3 (09) :858-863

← 1 2 3 4 →