Postmenopausal osteoporosis - Strategies for preventing bone loss, avoiding fracture

被引:25
作者
McGarry, KA
Kiel, DP
机构
[1] Rhode Isl Hosp, Div Gen Internal Med, Gen Internal Med Residency Program, Providence, RI 02903 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Hebrew Rehabil Ctr Aged, Boston, MA 02131 USA
关键词
D O I
10.3810/pgm.2000.09.1.1206
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoporosis causes fractures in more than a million and a half Americans each year. About 80% of these fractures occur in women, often at or shortly after menopause. Can the factors responsible for bone loss at menopause be modified to reduce risks? In this article, Drs McGarry and Kiel explain who should undergo bone density testing, which tests are most helpful, and who should be offered preventive therapy.
引用
收藏
页码:79 / +
页数:9
相关论文
共 26 条
[1]   CALCIUM SUPPLEMENTATION WITH AND WITHOUT HORMONE REPLACEMENT THERAPY TO PREVENT POSTMENOPAUSAL BONE LOSS [J].
ALOIA, JF ;
VASWANI, A ;
YEH, JK ;
ROSS, PL ;
FLASTER, E ;
DILMANIAN, FA .
ANNALS OF INTERNAL MEDICINE, 1994, 120 (02) :97-103
[2]   Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].
Black, DM ;
Cummings, SR ;
Karpf, DB ;
Cauley, JA ;
Thompson, DE ;
Nevitt, MC ;
Bauer, DC ;
Genant, HK ;
Haskell, WL ;
Marcus, R ;
Ott, SM ;
Torner, JC ;
Quandt, SA ;
Reiss, TF ;
Ensrud, KE .
LANCET, 1996, 348 (9041) :1535-1541
[3]   Monitoring osteoporosis therapy with bone densitometry - Misleading changes and regression to the man [J].
Cummings, SR ;
Palermo, L ;
Browner, W ;
Marcus, R ;
Wallace, R ;
Pearson, J ;
Blackwell, T ;
Eckert, S ;
Black, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (10) :1318-1321
[4]   The effect of raloxifene on risk of breast cancer in postmenopausal women - Results from the MORE randomized trial [J].
Cummings, SR ;
Eckert, S ;
Krueger, KA ;
Grady, D ;
Powles, TJ ;
Cauley, JA ;
Norton, L ;
Nickelsen, T ;
Bjarnason, NH ;
Morrow, M ;
Lippman, ME ;
Black, D ;
Glusman, JE ;
Costa, A ;
Jordan, VC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (23) :2189-2197
[5]   Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].
Cummings, SR ;
Black, DM ;
Thompson, DE ;
Applegate, WB ;
Barrett-Connor, E ;
Musliner, TA ;
Palermo, L ;
Prineas, R ;
Rubin, SM ;
Scott, JC ;
Vogt, T ;
Wallace, R ;
Yates, AJ ;
LaCroix, AZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082
[6]   Effect of calcium and vitamin D supplementation on bone, density in men and women 65 years of age or older [J].
DawsonHughes, B ;
Harris, SS ;
Krall, EA ;
Dallal, GE .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (10) :670-676
[7]   Treatment of postmenopausal osteoporosis [J].
Eastell, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (11) :736-746
[8]   Treatment with alendronate prevents fractures in women at highest risk - Results from the fracture intervention trial [J].
Ensrud, KE ;
Black, DM ;
Palermo, L ;
Bauer, DC ;
BarrettConnor, E ;
Quandt, SA ;
Thompson, DE ;
Karpf, DB .
ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (22) :2617-2624
[9]  
ENSRUD KE, 1995, J BONE MINER RES, V10, P1778
[10]   Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene -: Results from a 3-year randomized clinical trial [J].
Ettinger, B ;
Black, DM ;
Mitlak, BH ;
Knickerbocker, RK ;
Nickelsen, T ;
Genant, HK ;
Christiansen, C ;
Delmas, PD ;
Zanchetta, JR ;
Stakkestad, J ;
Glüer, CC ;
Krueger, K ;
Cohen, FJ ;
Eckert, S ;
Ensrud, KE ;
Avioli, LV ;
Lips, P ;
Cummings, SR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07) :637-645