Hormone replacement therapy with L-thyroxine promotes working memory and concentration in thyroidectomized female patients after differentiated thyroid carcinoma

被引：5

作者：

Cordes, Joachim ^{[1
,2
]}

Woite, Maya ^{[1
]}

Engelke, Christina ^{[1
]}

Regenbrecht, Gunnar ^{[1
]}

Kahl, Kai G. ^{[3
]}

Schmidt-Kraepelin, Christian ^{[1
]}

Henning, Uwe ^{[1
]}

Kamp, Daniel ^{[1
]}

Klimke, Ansgar ^{[1
,4
]}

机构：

[1] Heinrich Heine Univ, Med Fac, Dept Psychiat & Psychotherapy, Dusseldorf, Germany

[2] Florence Nightingale Hosp, Kaiserswerther Diakonie, Dusseldorf, Germany

[3] Hannover Med Sch, Zentrum Seel Gesundheit, Klin Psychiat Sozialpsychiat & Psychotherapie, Hannover, Germany

[4] Vitos Klinikum Hochtaunus, Friedrichsdorf, Germany

来源：

INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE | 2020年 / 55卷 / 02期

关键词：

depression; cognitive function; hypothyroidism; levothyroxine therapy; COGNITIVE FUNCTION; SUBCLINICAL HYPOTHYROIDISM; DYSFUNCTION;

D O I：

10.1177/0091217419885751

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective It is well established that long-term hypothyroidism is associated with cognitive deficits. Based on recent literature, we hypothesized that pharmacologically induced euthyroidism would lead to improved cognitive performance compared to a hypothyroid state. Methods We analyzed data from 14 nondepressed thyroidectomized female patients after differentiated thyroid carcinoma during hypothyroidism (due to a four-week withdrawal of thyroid hormone, T1) and euthyroidism brought about by substitution with L-thyroxine (T2). At both measurement points, patients completed a cognitive test battery as our dependent measure and Beck's Depression Inventory to control depressive states. Results A Wilcoxon signed-rank tests revealed a significant improvement in the Rey-Osterrieth complex figure test (cognitive reproduction), Z = -3.183, p = 0.001, and the D2 concentration score, Z = -1.992, p = 0.046 in euthyroidism compared to hypothyroidism. Conclusions Our results confirm that hormone replacement therapy with L-thyroxine promotes cognitive reproduction and concentration in thyroidectomized female patients after differentiated thyroid carcinoma.

引用

页码：114 / 122

页数：9

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