Asymmetric hydrogenation of ketones catalyzed by ruthenium hydride complexes of a beta-aminophosphine ligand derived from norephedrine

被引：74

作者：

Guo, RW ^{[1
]}

Lough, AJ ^{[1
]}

Morris, RH ^{[1
]}

Song, DT ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANOMETALLICS | 2004年 / 23卷 / 23期

关键词：

D O I：

10.1021/om049460h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series ruthenium complexes with the chiral P-N ligand (1R,2R)-PPh2CHPhCHMeNH2 derived from (1S,2R)-norephedrine are synthesized starting from the complexes RuHCl(PPh3)(3) or RuHCl(P-P)(PPh3) (P-P= (R)-binap or (S)-binap). These are precatalysts for the efficient asymmetric hydrogenation of simple ketones. For the hydrogenation of acetophenone to I-phenylethanol, the enantioselectivity observed can be related to the structure of the precatalysts determined by X-ray diffraction. This relationship breaks down for the hydrogenation of pinacolone.

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页码：5524 / 5529

页数：6

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