Evaluation of Antifouling Potential and Ecotoxicity of Secondary Metabolites Derived from Red Algae of the Genus Laurencia

被引：16

作者：

Protopapa, Maria ^{[1
]}

Kotsiri, Manto ^{[1
]}

Mouratidis, Sofoklis ^{[1
]}

Roussis, Vassilios ^{[2
]}

Ioannou, Efstathia ^{[2
]}

Dedos, Skarlatos G. ^{[1
]}

机构：

[1] Univ Athens, Dept Biol, Athens 15784, Greece

[2] Univ Athens, Dept Pharm, Sect Pharmacognosy & Chem Nat Prod, Athens 15771, Greece

来源：

MARINE DRUGS | 2019年 / 17卷 / 11期

关键词：

Laurencia; red algae; biofouling; ecotoxicity; Amphibalanus amphitrite; barnacles; perforenol; MARINE NATURAL-PRODUCTS; CHEMICAL DEFENSE; SETTLEMENT; BACTERIA; SURFACE; LOCALIZATION; INHIBITION; TRANSPORT; TOXICITY; PROTEIN;

D O I：

10.3390/md17110646

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Red algae of the genus Laurencia are known to biosynthesize and secrete an immense variety of secondary metabolites possessing a spectrum of biological activities against bacteria, invertebrates and mammalian cell lines. Following a rigorous cross-species screening process, herein we report the antifouling potential of 25 secondary metabolites derived from species of the genus Laurencia, as well as the thorough evaluation of the ecotoxicity of selected metabolites against non-target marine arthropods and vertebrate cell lines. A number of these secondary metabolites exhibited potent antifouling activity and performed well in all screening tests. Our results show that perforenol (9) possesses similar antifouling activity with that already described for bromosphaerol, which is used herein as a benchmark.

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页数：15

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