Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015

被引：67

作者：

Genus, Tracey S. E. ^{[1
,2
]}

Bouvier, Catherine ^{[1
]}

Wong, Kwok F. ^{[2
]}

Srirajaskanthan, Rajaventhan ^{[3
,4
]}

Rous, Brian A. ^{[5
]}

Talbot, Denis C. ^{[6
]}

Valle, Juan W. ^{[7
]}

Khan, Mohid ^{[8
]}

Pearce, Neil ^{[9
]}

Elshafie, Mona ^{[10
]}

Reed, Nicholas S. ^{[11
]}

Morgan, Eileen ^{[12
]}

Deas, Andrew ^{[13
]}

White, Ceri ^{[14
]}

Huws, Dyfed ^{[14
]}

Ramage, John ^{[3
,4
]}

机构：

[1] Neuroendocrine Tumour Patients Fdn, Royal Leamington Spa, England

[2] Publ Hlth England, Natl Canc Registrat & Anal Serv, Birmingham, W Midlands, England

[3] Kings Coll Hosp London, Dept Gastroenterol, London, England

[4] Kings Coll Hosp London, Neuroendocrine Tumour Unit, ENETS Ctr Excellence, London, England

[5] Publ Hlth England, Natl Canc Registrat & Anal Serv, Cambridge, England

[6] Oxford Univ Hosp Trust, ENETS Ctr Excellence, Oxford, England

[7] Christie NHS Fdn Trust, Dept Med Oncol, Manchester, Lancs, England

[8] Cardiff & Vale Univ Hosp Board, Univ Wales Hosp, Dept Gastroenterol, Cardiff, S Glam, Wales

[9] Univ Hosp Southampton NHS Fdn Trust, Dept Hepatobiliary & Pancreat Surg, Southampton, Hants, England

[10] Univ Hosp Birmingham NHS Fdn Trust, Dept Cellular Pathol, Birmingham, W Midlands, England

[11] Gartnavel Royal Hosp, Beatson Oncol Ctr, Glasgow, Lanark, Scotland

[12] Queens Univ Belfast, Ctr Publ Hlth, Northern Ireland Canc Registry, Belfast, Antrim, North Ireland

[13] NHS Natl Serv Scotland, Informat Serv Div, Edinburgh, Midlothian, Scotland

[14] Publ Hlth Wales, Welsh Canc Intelligence & Surveillance Unit, Cardiff, S Glam, Wales

来源：

BRITISH JOURNAL OF CANCER | 2019年 / 121卷 / 11期

关键词：

TUMORS; EPIDEMIOLOGY; CARCINOMA;

D O I：

10.1038/s41416-019-0606-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS: Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013-2015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagnosis at stage IV and morphology. RESULTS: A total of 15,222 NENs were identified, with an ASR (2013-2015 combined) of 8.6 per 100,000 (95% CI 8.5-8.7); 4.6 per 100 000 (95% CI, 4.5-4.7) for gastro-entero-pancreatic (GEP) NENs. The 1YS was 75% (95% CI, 73.9-75.4) varying significantly by sex. Site and morphology were prognostic. NENs (predominantly small cell carcinomas) in the oesophagus, bladder, prostate, and female reproductive organs had a poorer outcome and were three times more likely to be diagnosed at stage IV than non-NENs. CONCLUSION: Advanced stage at diagnosis with significantly poorer outcomes of some NENs compared with non-NENs at the same anatomical site, highlight the need for improved access to specialist services and targeted service improvement.

引用

页码：966 / 972

页数：7

共 23 条

[1]

[Anonymous], 2015, AJCC Cancer Staging Manual

[2]

[Anonymous], INT UNION CANC TNM C

[3]

Bannister N., 2016, Cancer survival by stage at diagnosis for England (experimental statistics)

[4]

Bosman FT, 2010, WHO Classification of tumors of the digestive system

[5] Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity [J].

Brathwaite, Shayna ;

Rock, Jonathan ;

Yearsley, Martha M. ;

Bekaii-Saab, Tanios ;

Wei, Lai ;

Frankel, Wendy L. ;

Hays, John ;

Wu, Christina ;

Abdel-Misih, Sherif .

ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (07) :2281-2286

[6]

Cronin KA, 2000, STAT MED, V19, P1729, DOI 10.1002/1097-0258(20000715)19:13<1729::AID-SIM484>3.0.CO

[7]

2-9

[8] Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States [J].

Dasari, Arvind ;

Shen, Chan ;

Halperin, Daniel ;

Zhao, Bo ;

Zhou, Shouhao ;

Xu, Ying ;

Shih, Tina ;

Yao, James C. .

JAMA ONCOLOGY, 2017, 3 (10) :1335-1342

[9] Neuroendocrine Tumors of the Gallbladder An Evaluation and Reassessment of Management Strategy [J].

Eltawil, Karim M. ;

Gustafsson, Bjorn I. ;

Kidd, Mark ;

Modlin, Irvin M. .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2010, 44 (10) :687-695

[10] Cervical cancer - does the morphological subtype affect survival rates? [J].

Emmett, Marta ;

Gildea, Carolynn ;

Nordin, Andrew ;

Hirschowitz, Lynn ;

Poole, Jason .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2018, 38 (04) :548-555

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