Total synthesis of aculeatins A and B via a tethered oxa-Michael approach

被引：51

作者：

Chandrasekhar, S. ^{[1
]}

Rambabu, Ch. ^{[1
]}

Shyamsunder, T. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 27期

关键词：

aculeatin; marouka allylation; oxa-michael reaction; spirocyclic natural products;

D O I：

10.1016/j.tetlet.2007.05.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled total synthesis of aculeatins A and B has been achieved in eight steps and in 15% overall yield. The key feature of this synthetic approach is the application of a Marouka allylation and tethered intrarmolecular oxa-Michael reaction to install the required stereocentres on the tetrahydropyran ring. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4683 / 4685

页数：3

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