Heat generation of surface-modified magnetic γ-Fe2O3 nanoparticles in applied alternating magnetic field

被引：10
作者：
Babic, Michal [1 ]
Horak, Daniel [1 ]
Molcan, Matus [2 ]
Timko, Milan [2 ]
机构：
[1] Acad Sci Czech Republ, Inst Macromol Chem, Heyrovskeho Sq 2, CR-16206 Prague 6, Czech Republic
[2] Slovak Acad Sci, Inst Expt Phys, Watsonova 47, Kosice 04001, Slovakia
来源：
JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2017年 / 50卷 / 34期
关键词：
iron oxide; nanoparticles; poly(N; N-dimethylacrylamide); D-mannose; heating capacity; hyperthermia; IRON-OXIDE NANOPARTICLES; PARTICLES; FLUID;
D O I：
10.1088/1361-6463/aa7bcb
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
In this report, we show preparation of colloidally stable poly(N,N-dimethylacrylamide-coacrylic acid) (DMA)- and D-mannose (MAN)-coated maghemite nanoparticles and their ability to generate heat in an alternating magnetic field, which could make the particles applicable for hyperthermic therapy of cancer. The particles are obtained by coprecipitation reaction and characterized by transmission electron microscopy, dynamic light scattering, and AC calorimetric measurement of heat generated by the particles. While the dry particles were ca. 10 nm in diameter, their hydrodynamic size in water was within the range of 100 nm. Heating characteristics were measured in an LC circuit with a maximum field intensity of 6.8 kA . m(-1) and frequency 190 kHz. The specific absorption rates of gamma-Fe2O3, PDM@gamma-Fe2O3, and MAN@gamma-Fe2O3 nanoparticles were extrapolated to 10 kA . m(-1), reaching about 15 W . g(-1).
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页数：6
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