Gap junction coding genes and schizophrenia: a genetic association study

被引：5

作者：

Aleksic, Branko

Ishihara, Ryoko

Takahashi, Nagahide

Maeno, Nobuhisa

Ji, Xiaofei

Saito, Shinichi

Inada, Toshiya

Ozaki, Norio

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Psychiat, Showa Ku, Aichi 4668550, Japan

[2] Teikyo Univ, Sch Med, Chiba Med Ctr, Dept Psychiat, Chiba 2990111, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2007年 / 52卷 / 06期

关键词：

gap junction; Panx2; Cx36; schizophrenia; genetic association; case control; gamma band oscillation;

D O I：

10.1007/s10038-007-0142-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (Panx2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of Panx2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population.

引用

页码：498 / 501

页数：4

共 29 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[3] Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder [J].

Braff, David L. ;

Freedman, Robert ;

Schork, Nicholas J. ;

Gottesman, Irving I. .

SCHIZOPHRENIA BULLETIN, 2007, 33 (01) :21-32

[4] Pannexins, a family of gap junction proteins expressed in brain [J].

Bruzzone, R ;

Hormuzdi, SG ;

Barbe, MT ;

Herb, A ;

Monyer, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13644-13649

[5]

Buhl DL, 2003, J NEUROSCI, V23, P1013

[6] Population genetics - making sense out of sequence [J].

Chakravarti, A .

NATURE GENETICS, 1999, 21 (Suppl 1) :56-60

[7] Expression of Cx36 in mammalian neurons [J].

Condorelli, DF ;

Belluardo, N ;

Trovato-Salinaro, A ;

Mudò, G .

BRAIN RESEARCH REVIEWS, 2000, 32 (01) :72-85

[8] Electrical synapses in the mammalian brain [J].

Connors, BW ;

Long, MA .

ANNUAL REVIEW OF NEUROSCIENCE, 2004, 27 :393-418

[9] Pedigree disequilibrium tests for multilocus haplotypes [J].

Dudbridge, F .

GENETIC EPIDEMIOLOGY, 2003, 25 (02) :115-121

[10] The endophenotype concept in psychiatry: Etymology and strategic intentions [J].

Gottesman, II ;

Gould, TD .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (04) :636-645

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