Leucine metabolites do not induce changes in phase angle, bioimpedance vector analysis patterns, and strength in resistance trained men

We aimed to assess the effects of off-the-shelf leucine metabolite supplements on phase angle (PhA), bioimpedance vector analysis (BIVA) patterns and strength during an 8-week resistance training protocol. Fifty-three male participants were allocated into 4 groups: alpha-hydroxyisocaproic acid (n =12, age = 30.9 +/- 9.3 years), beta-hydroxy-beta-methylbutyrate free acid (n =12, age = 31.0 +/- 9.3 years), calcium beta-hydroxy-beta-methylbutyrate (n =15, age = 32.1 +/- 5.2 years) or placebo (n =14, age = 28.9 +/- 6.6 years). Bioimpedance parameters and 1-repetition maximum (IRM) for back squat and bench press were assessed at baseline and at the end of weeks 4 and 8. Additionally, fat-free mass and fat mass were evaluated by dual-energy X-ray absorptiometry. No statistically group by time interactions were found, even adjusting for age. PhA and vector did not change over the training period, while time-dependent increases were observed for 1RM back squat and 1RM bench press. A direct association was observed between PhA and 1RM bench press changes (whole sample), while PhA and strength were correlated throughout the study, even when adjusting for fat-free mass and percentage of fat mass. Leucine metabolites have no effect on PhA, BIVA patterns or strength during an 8-week resistance training program, in resistance trained subjects. Novelty: Supplementation with leucine metabolites is not a supplementation strategy that improves bioelectrical phase angle, cellular health, and strength after an 8-week resistance training program. When constuning a high protein diet, none of the alpha-hydroxyisocaproic acid, beta-hydroxy-beta-methylbutyrate free acid, and calcium beta-hydroxy-beta-methylbutyrate metabolites resulted in an ergogenic effect in resistance trained men.