Rash associated with first dose of antituberculosis polytherapy: responsibility of pyrazinamide?

被引：8

作者：

Olivier, C

Radal, M

Mazaud, S

Jonville-Bera, AP

Martel, C

Autret, E

机构：

[1] Hop Louis Mourier, Serv Pediat Gen, F-92000 Colombes, France

[2] Hop Bretonneau, Serv Pharmacol Clin, F-37044 Tours, France

[3] Hop Bretonneau, Ctr Reg Pharmacovigilance & Renseignement Medicam, F-37044 Tours, France

来源：

ARCHIVES DE PEDIATRIE | 1998年 / 5卷 / 03期

关键词：

isoniazid; rifamycins; pyrazinamide; ethambutol; erythema; dermatitis medicamentosa; substance use disorders;

D O I：

10.1016/S0929-693X(97)89371-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a rash after the first dose of antituberculosis polytherapy which raises questions concerning procedures to be followed. Case report. - An 8-year-old child presented with a pruritic rash 1.5 hours after the first dose of isoniazide, rifampicine, pyrazinamide and ethambutol was simultaneously administered, which did not recur after successive re-administration of isoniazide and rifampicine. Pyrazinamide, which was re-administered last induced a recurrence. Slower pyrazinamide re-administration allowed continuation of treatment. Conclusion. - A protocol for re-administration of the four the four drugs is suggested. (C) 1998 Elsevier, Paris.

引用

页码：289 / 290

页数：2