Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo

被引：12
|
作者：
Liu, Ying [1 ,2 ]
Hu, Xiaoxiao [3 ,4 ]
Wang, Linlin [1 ,2 ]
Liu, Xiangjun [1 ,2 ]
Bing, Tao [1 ,2 ]
Tan, Weihong [3 ,4 ,5 ]
Shangguan, Dihua [1 ,2 ]
机构：
[1] Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Life Sci, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China
[4] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
[5] Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Hlth Canc Ctr,Genet Inst,McKnight Brain Inst, Gainesville, FL 32611 USA
来源：
DYES AND PIGMENTS | 2017年 / 145卷
关键词：
Photodynamic therapy; Photosensitizers; Quinacridone derivatives; Photo-toxicity; Cancer; METHYLENE-BLUE; ROSE-BENGAL; THERAPY; VITRO; NANOPARTICLES; SENSITIZERS; HYPERICIN; DYE;
D O I：
10.1016/j.dyepig.2017.06.003
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The lack of ideal photosensitizers is the major limitation for clinical photodynamic therapy (PDT). Quinacridone (QA) is a mass-produced industrial organic pigment. QA derivatives are widely investigated for many applications in various fields, but rarely involved in biological applications. Here we report the PDT effects of N,N'-bis(methylpiperazinylpentyl) QA (QAP) in cells and in vivo. QAP shows low dark -toxicity and high photo-toxicity in cells through generating reactive oxygen species (ROS) under irradiation; and greatly inhibits the tumor growth in a mouse subcutaneous xenograft model after irradiation with a 532 nm laser. The high photodynamic efficiency of QAP shows the great potential of QA derivatives to be a new class of leading compound of photosensitizers in PDT. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：168 / 173
页数：6
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