Resistant Hypertension A Clinical Perspective

被引：5

作者：

Hannah-Shmouni, Fady ^{[1
]}

Gubbi, Sriram ^{[2
]}

Spence, J. David ^{[3
]}

Stratakis, Constantine A. ^{[1
]}

Koch, Christian A. ^{[4
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Internal Med Endocrinol Hypertens & Metab Genet, Sect Endocrinol & Genet, NIH, 10 Ctr Dr,MSC 1109, Bethesda, MD 20892 USA

[2] NIDDK, Diabet Endocrinol & Obes Branch, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA

[3] Western Univ, Robarts Res Inst, Stroke Prevent & Atherosclerosis Res Ctr, 1400 Western Rd, London, ON N6G 2V4, Canada

[4] Univ Tennessee, Hlth Sci Ctr, 910 Madison Ave, Memphis, TN 38163 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2019年 / 48卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Hypertension; Resistant hypertension; Primary aldosteronism; Renin; Aldosterone; Liddle syndrome; Amiloride; WHITE-COAT HYPERTENSION; EPITHELIAL SODIUM-CHANNEL; RENAL-ARTERY STENOSIS; BLOOD-PRESSURE; PRIMARY ALDOSTERONISM; PLASMA-RENIN; UNCONTROLLED HYPERTENSION; STIMULATED RENIN; HIGH PREVALENCE; SCREENING-TEST;

D O I：

10.1016/j.ecl.2019.08.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resistant hypertension is a common clinical entity, defined as suboptimal blood pressure response to multiple therapies after excluding medication nonadherence and secondary forms of hypertension. Patients with resistant hypertension generally share several comorbidities. Resistant hypertension is more common in individuals of African descent. Blood pressure should be optimized using multiple strategies, including lifestyle changes and single-pill combination therapies, with the aim of reducing cardiovascular events while reducing side effects from using antihypertensive therapy. A renin/aldosterone-based diagnostic and treatment approach will help tailor therapy. The use of mineralocorticoid receptor antagonists or amiloride as appropriate is favored.

引用

页码：811 / +

页数：19

共 97 条

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