Reeling in the Zebrafish Cancer Models

被引：14

作者：

McConnell, Alicia M. ^{[1
,2
,3
,4
,5
]}

Noonan, Haley R. ^{[1
,2
,3
,4
,5
,6
]}

Zon, Leonard I. ^{[1
,2
,3
,4
,5
,7
,8
]}

机构：

[1] Boston Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Harvard Stem Cell Inst, Boston, MA 02138 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Harvard Med Sch, Biol & Biomed Sci Program, Boston, MA 02115 USA

[7] Harvard Univ, Stem Cell & Regenerat Biol Dept, Boston, MA 02138 USA

[8] Harvard Univ, Howard Hughes Med Inst, Boston, MA 02138 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 5, 2021 | 2021年 / 5卷

关键词：

zebrafish; cancer; transgenic; modeling; genetics; tumor; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; GERM-CELL TUMORS; NEURAL-CREST; SELF-RENEWAL; MYELOPROLIFERATIVE NEOPLASM; HEPATOCELLULAR-CARCINOMA; ONCOGENE EXPRESSION; LIVER TUMORIGENESIS; REGULATES GROWTH;

D O I：

10.1146/annurev-cancerbio-051320-014135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Zebrafish are rapidly becoming a leading model organism for cancer research. The genetic pathways driving cancer are highly conserved between zebrafish and humans, and the ability to easily manipulate the zebrafish genome to rapidly generate transgenic animals makes zebrafish an excellent model organism. Transgenic zebrafish containing complex, patient-relevant genotypes have been used to model many cancer types. Here we present a comprehensive review of transgenic zebrafish cancer models as a resource to the field and highlight important areas of cancer biology that have yet to be studied in the fish. The ability to image cancer cells and niche biology in an endogenous tumor makes zebrafish an indispensable model organism in which we can further understand the mechanisms that drive tumorigenesis and screen for potential new cancer therapies.

引用

页码：331 / 350

页数：20

共 137 条

[1] Tissue-specific gene targeting using CRISPR/Cas9 [J].

Ablain, J. ;

Zon, L. I. .

ZEBRAFISH: GENETICS, GENOMICS, AND TRANSCRIPTOMICS, 4TH EDITION, 2016, 135 :189-202

[2] Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma [J].

Ablain, Julien ;

Xu, Mengshu ;

Rothschild, Harriet ;

Jordan, Richard C. ;

Mito, Jeffrey K. ;

Daniels, Brianne H. ;

Bell, Caitlin F. ;

Joseph, Nancy M. ;

Wu, Hong ;

Bastian, Boris C. ;

Zon, Leonard I. ;

Yeh, Iwei .

SCIENCE, 2018, 362 (6418) :1055-+

[3] A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish [J].

Ablain, Julien ;

Durand, Ellen M. ;

Yang, Song ;

Zhou, Yi ;

Zon, Leonard I. .

DEVELOPMENTAL CELL, 2015, 32 (06) :756-764

[4]

ACS (Am. Cancer Soc.), 2020, TECH REP

[5] Genomic Classification of Cutaneous Melanoma [J].

Akbani, Rehan ;

Akdemir, Kadir C. ;

Aksoy, B. Arman ;

Albert, Monique ;

Ally, Adrian ;

Amin, Samirkumar B. ;

Arachchi, Harindra ;

Arora, Arshi ;

Auman, J. Todd ;

Ayala, Brenda ;

Baboud, Julien ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barnabas, Nandita ;

Bartlett, John ;

Bartlett, Pam ;

Bastian, Boris C. ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Belyaev, Dmitry ;

Benz, Christopher ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bir, Natalie ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Boland, Genevieve M. ;

Bono, Riccardo ;

Bootwalla, Moiz S. ;

Bosenberg, Marcus ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brockway-Lunardi, Laura ;

Brooks, Denise ;

Brzezinski, Jakub ;

Bshara, Wiam ;

Buda, Elizabeth ;

Burns, William R. ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Calderone, Tiffany ;

Cappellini, Giancarlo Antonini ;

Carter, Candace ;

Carter, Scott L. ;

Cherney, Lynn ;

Cherniack, Andrew D. ;

Chevalier, Aaron ;

Chin, Lynda .

CELL, 2015, 161 (07) :1681-1696

[6] Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway [J].

Alghisi, E. ;

Distel, M. ;

Malagola, M. ;

Anelli, V. ;

Santoriello, C. ;

Herwig, L. ;

Krudewig, A. ;

Henkel, C. V. ;

Russo, D. ;

Mione, M. C. .

LEUKEMIA, 2013, 27 (11) :2229-2241

[7] Many ribosomal protein genes are cancer genes in zebrafish [J].

Amsterdam, A ;

Sadler, KC ;

Lai, K ;

Farrington, S ;

Bronson, RT ;

Lees, JA ;

Hopkins, N .

PLOS BIOLOGY, 2004, 2 (05) :690-698

[8]

Anelli V, 2017, ELIFE, V6, DOI [10.7554/eLife.20728.001, 10.7554/eLife.20728]

[9] Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic krasV12 expression in transgenic zebrafish [J].

Anh Tuan Nguyen ;

Koh, Vivien ;

Spitsbergen, Jan M. ;

Gong, Zhiyuan .

SCIENTIFIC REPORTS, 2016, 6

[10] An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening [J].

Anh Tuan Nguyen ;

Emelyanov, Alexander ;

Koh, Chor Hui Vivien ;

Spitsbergen, Jan M. ;

Parinov, Serguei ;

Gong, Zhiyuan .

DISEASE MODELS & MECHANISMS, 2012, 5 (01) :63-72

← 1 2 3 4 5 6 7 8 9 10 →