ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

被引：63
|
作者：
Wu, Zhigiang [1 ,2 ]
Yang, Li [1 ,2 ]
Ren, Xianwen [1 ,2 ]
Zhang, Junpeng [4 ]
Yang, Fan [1 ,2 ]
Zhang, Shuyi [5 ]
Jin, Qi [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, MOH Key Lab Syst Biol Pathogens, Inst Pathogen Biol, Beijing 100730, Peoples R China
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
[4] E China Normal Univ, Inst Estuarine & Coastal Res, State Key Lab Estuarine & Coastal Res, Shanghai 200062, Peoples R China
[5] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110161, Peoples R China
来源：
JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 04期
基金：
中国国家自然科学基金;
关键词：
severe acute respiratory syndrome coronavirus; origin; bats; ORF8; SARS CORONAVIRUS; EXPRESSION; EVOLUTION; PROTEIN; 8B;
D O I：
10.1093/infdis/jiv476
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)-like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.
引用
收藏
页码：579 / 583
页数：5
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