Beyond Viral Interferon Regulatory Factors: Immune Evasion Strategies

被引：11

作者：

Myoung, Jinjong ^{[1
,2
]}

Lee, Shin-Ae ^{[3
]}

Lee, Hye-Ra ^{[4
]}

机构：

[1] Jeonbuk Natl Univ, Genet Engn Res Inst, Korea Zoonosis Res Inst, Jeonju 54531, South Korea

[2] Jeonbuk Natl Univ, Coll Nat Sci, Dept Bioact Mat Sci, Jeonju 54531, South Korea

[3] Univ Southern Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90007 USA

[4] Korea Univ, Dept Biotechnol & Bioinformat, Coll Sci & Technol, Sejong 30019, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2019年 / 29卷 / 12期

关键词：

KSHV; viral interferon regulatory factor; immune evasion strategy; PRR-mediated signaling pathway; apoptosis pathway; KAPOSIS-SARCOMA; SIGNAL-TRANSDUCTION; INHIBITION; KSHV; TRANSCRIPTION; PATHWAY; PROTEIN; P53; IDENTIFICATION; ACTIVATION;

D O I：

10.4014/jmb.1910.10004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi's sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.

引用

页码：1873 / 1881

页数：9

共 55 条

[1] Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein
Areste, Cristina
Mutocheluh, Mohamed
Blackbourn, David J.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (35) : 23272 - 23285
[2] Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
Baresova, Petra
Pitha, Paula M.
Lubyova, Barbora
[J]. JOURNAL OF VIROLOGY, 2013, 87 (17) : 9398 - 9410
[3] Burysek L, 1999, J VIROL, V73, P7334
[4] Burysek L, 1999, J HUMAN VIROL, V2, P19
[5] Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase
Burysek, L
Pitha, PM
[J]. JOURNAL OF VIROLOGY, 2001, 75 (05) : 2345 - 2352
[6] Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7
Chavoshi, Sara
Egorova, Olga
Lacdao, Ira Kay
Farhadi, Sahar
Sheng, Yi
Saridakis, Vivian
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (12) : 6281 - 6291
[7] Human Herpesvirus 8 Interferon Regulatory Factor-Mediated BH3-Only Protein Inhibition via Bid BH3-B Mimicry
Choi, Young Bong
Sandford, Gordon
Nicholas, John
[J]. PLOS PATHOGENS, 2012, 8 (06)
[8] Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein
Fuld, S
Cunningham, C
Klucher, K
Davison, AJ
Blackbourn, DJ
[J]. JOURNAL OF VIROLOGY, 2006, 80 (06) : 3092 - 3097
[9] Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
Fulda, S.
Debatin, K. -M
[J]. ONCOGENE, 2006, 25 (34) : 4798 - 4811
[10] KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
Ganem, Don
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (04) : 939 - 949

← 1 2 3 4 5 6 →