Glial cells with differential neurite growth-modulating properties probed by atomic force microscopy

被引：16
作者：
Weissmüller, G
Garcia-Abreu, J
Bisch, PM
Neto, VM
Cavalcante, LA
机构：
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21949900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Anat, BR-21949900 Rio De Janeiro, Brazil
来源：
NEUROSCIENCE RESEARCH | 2000年 / 38卷 / 02期
关键词：
extracellular matrix; atomic force microscopy; astrocytes; heparan sulfate; proteoglycans; fibril;
D O I：
10.1016/S0168-0102(00)00159-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Lateral (L) and medial (M) midbrain astrocytes differ in their ability to support neuritic growth (L, permissive; M, non-permissive) with properties of M glia depending on heparan sulfate (HS). Here we show by atomic force microscopy that the surfaces of formaldehyde-fixed astrocytes differ by conspicuous 250 nm protrusions in L and by a HS-dependent fibrillar network in M glia, thus, demonstrating correlations between cell surface morphology and functional properties. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：217 / 220
页数：4
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