One-pot three-component synthesis of a new series of tetrahydrobenzofuran-chromone conjugates

被引：1
作者：
Teimouri, Mohammad Bagher [1 ]
Yousefi, Samira [1 ]
Meydani, Ali [1 ]
机构：
[1] Kharazmi Univ, Fac Chem, Tehran, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 13期
关键词：
Isocyanide; multicomponent reactions; tetrahydrobenzofuran-chromone conjugate; SESQUITERPENE HYDROQUINONE DERIVATIVES; MULTICOMPONENT REACTIONS; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; ISOCYANIDES; INTERLEUKIN-8; ANTIOXIDANT; ACID;
D O I：
10.1080/00397911.2021.1918169
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot three-component protocol for the synthesis of novel tetrahydrobenzofuran-chromone conjugates using 3-formylchromones and 1,3-cyclohexandiones in the presence of a variety of alkyl or aryl isocyanides was developed. The reaction sequence consists of an initial Knoevenagel condensation of aromatic aldehydes with 1,3-cyclohexandione derivatives, followed by a [4 + 1] cycloaddition of with isocyanides, and then imine-enamine tautomerization to afford the products.
引用
收藏
页码：1974 / 1981
页数：8
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