Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation

被引：8

作者：

Gong, Pei-Xue ^{[1
]}

Xu, Fangning ^{[1
]}

Cheng, Lu ^{[1
]}

Gong, Xu ^{[1
]}

Zhang, Jie ^{[1
]}

Gu, Wei-Jin ^{[1
]}

Han, Wei ^{[1
,2
]}

机构：

[1] Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China

[2] Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Key Lab Appl Photochem, Nanjing 210023, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 48期

关键词：

LITHOCHOLIC ACID; TRIFLUOROMETHYLATION; CONVERSION; EFFICIENT; STRATEGY; ALKENES; KETONES; NICKEL;

D O I：

10.1039/d1cc01536b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical and general iron-catalyzed domino decarboxylation-oxidation of alpha,beta-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.

引用

页码：5905 / 5908

页数：4

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