共 98 条
Microcantilever-based platforms as biosensing tools
被引:135
作者:

Alvarez, Mar
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机构: CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Res Ctr Nanosci & Nanotechnol, Bellaterra 08193, Spain

Lechuga, Laura M.
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h-index: 0
机构:
CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Res Ctr Nanosci & Nanotechnol, Bellaterra 08193, Spain CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Res Ctr Nanosci & Nanotechnol, Bellaterra 08193, Spain
机构:
[1] CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Res Ctr Nanosci & Nanotechnol, Bellaterra 08193, Spain
来源:
关键词:
PROSTATE-SPECIFIC ANTIGEN;
SELF-ASSEMBLED MONOLAYERS;
QUARTZ-CRYSTAL MICROBALANCE;
CANTILEVER ARRAY SENSORS;
LABEL-FREE DETECTION;
SURFACE STRESS;
NANOMECHANICAL BIOSENSORS;
CONFORMATIONAL-CHANGE;
RECEPTOR MOLECULES;
DNA HYBRIDIZATION;
D O I:
10.1039/b908503n
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
The fast and progressive growth of the biotechnology and pharmaceutical fields forces the development of new and powerful sensing techniques for process optimization and detection of biomolecules at very low concentrations. During the last years, the simplest MEMS structures, i.e. microcantilevers, have become an emerging and promising technology for biosensing applications, due to their small size, fast response, high sensitivity and their compatible integration into "lab-on-a-chip'' devices. This article provides an overview of some of the most interesting bio-detections carried out during the last 2-3 years with the microcantilever-based platforms, which highlight the continuous expansion of this kind of sensor in the medical diagnosis field, reaching limits of detection at the single molecule level.
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页码:827 / 836
页数:10
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