Mechanism of pharmacological effect of Angelica essential oil on anxiety based on network pharmacology and molecular docking

被引：1
作者：
Liu, Xiaoli [1 ]
Zhang, Xiaofei [2 ,3 ]
Wang, Fang [3 ]
Xu, Jie [3 ]
Yang, Ming [1 ,3 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China
[2] Shaanxi Univ Chinese Med, Pharm Coll, Xianyang City 712046, Shaanxi, Peoples R China
[3] Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat Tradit Chinese Med, Nanchang 330000, Jiangxi, Peoples R China
来源：
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2021年 / 20卷 / 04期
关键词：
Angelica Essential oil; Anxiety; Network pharmacology; Molecular Docking; Pharmacological; LIGUSTILIDE; DATABASE;
D O I：
10.4314/tjpr.v20i4.19
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: To investigate the pharmacological effect of Angelica essential oil (AEO) on anxiety disorder and the mechanism of action involved, using network pharmacology and molecular docking. Method: Chemical compositions of AEO were determined using gas chromatography-mass spectrometry (GC-MS). The potential targets involved in the effect of AEO on anxiety were predicted by searching Bioinformatics databases. Cytoscape software was applied for networks construction. Analysis of Gene Ontology (GO) and pathway was done via R Programming Language, while molecular docking analysis was conducted by Autodock vina software. Results: Network analysis showed that there were 10 bioactive components and 34 potential targets. The potential targets were distributed in cerebellar cortex, basic ganglia, hippocampal formation, amygdala, pons and medulla and liver. AEO was involved in multiple biological processes (BP), cell components (CC) and molecular functions (MF) associated with anxiety disorder. Molecular docking revealed good binding affinity between the major bioactive components and targets. Conclusion: This study has revealed the pharmacological mechanism involved in the effect of AEO on anxiety, through network pharmacology and molecular docking. The pharmacological mechanism provides a firm theoretical basis for further studies in this area of research.
引用
收藏
页码：789 / 796
页数：8
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