Different functional connectivity and network topology in behavioral variant of frontotemporal dementia and Alzheimer's disease: an EEG study

被引：121

作者：

Yu, Meichen ^{[1
,2
]}

Gouw, Alida A. ^{[1
,2
,3
,4
]}

Hillebrand, Arjan ^{[1
,2
]}

Tijms, Betty M. ^{[3
,4
]}

Stam, Cornelis Jan ^{[1
,2
]}

van Straaten, Elisabeth C. W. ^{[1
,2
]}

Pijnenburg, Yolande A. L. ^{[3
,4
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Clin Neurophysiol, de Boelelaan 1118, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, MEG Ctr, de Boelelaan 1118, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

来源：

NEUROBIOLOGY OF AGING | 2016年 / 42卷

关键词：

Alzheimer's disease; Behavioral variant of frontotemporal dementia; Electroencephalography; Functional connectivity; Network topology; Subjective cognitive decline; GRAPH-THEORETICAL ANALYSIS; COMPLEX BRAIN NETWORKS; DIAGNOSTIC-CRITERIA; QUANTITATIVE EEG; MEMORY TASK; SYNCHRONIZATION; ORGANIZATION; DYSFUNCTION; SALIENCE; ECONOMY;

D O I：

10.1016/j.neurobiolaging.2016.03.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated whether the functional connectivity and network topology in 69 Alzheimer's disease (AD), 48 behavioral variant of frontotemporal dementia (bvFTD) patients, and 64 individuals with subjective cognitive decline are different using resting-state electroencephalography recordings. Functional connectivity between all pairs of electroencephalography channels was assessed using the phase lag index (PLI). We subsequently calculated PLI-weighted networks, from which minimum spanning trees (MSTs) were constructed. Finally, we investigated the hierarchical clustering organization of the MSTs. Functional connectivity analysis showed frequency-dependent results: in the delta band, bvFTD showed highest whole-brain PLI; in the theta band, the whole-brain PLI in AD was higher than that in bvFTD; in the alpha band, AD showed lower whole-brain PLI compared with bvFTD and subjective cognitive decline. The MST results indicate that frontal networks appear to be selectively involved in bvFTD against the background of preserved global efficiency, whereas parietal and occipital loss of network organization in AD is accompanied by global efficiency loss. Our findings suggest different pathophysiological mechanisms in these 2 separate neurodegenerative disorders. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：150 / 162

页数：13

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