European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

被引：84

作者：

Nielsen, J. ^{[1
]}

Vestergaard, L. S. ^{[1
]}

Richter, L. ^{[2
]}

Schmid, D. ^{[2
]}

Bustos, N. ^{[3
]}

Asikainen, T. ^{[3
]}

Trebbien, R. ^{[1
]}

Denissov, G. ^{[4
]}

Innos, K. ^{[4
]}

Virtanen, M. J. ^{[5
]}

Fouillet, A. ^{[6
]}

Lytras, T. ^{[7
]}

Gkolfinopoulou, K. ^{[7
]}

an der Heiden, M. ^{[8
]}

Grabenhenrich, L. ^{[8
]}

Uphoff, H. ^{[9
]}

Paldy, A. ^{[10
]}

Bobvos, J. ^{[11
]}

Domegan, L. ^{[12
]}

O'Donnell, J. ^{[12
]}

Scortichini, M. ^{[13
]}

de Martino, A. ^{[14
]}

Mossong, J. ^{[15
]}

England, K. ^{[16
]}

Melillo, J. ^{[17
]}

van Asten, L. ^{[18
]}

de lange, M. M. A. ^{[18
]}

Tonnessen, R. ^{[19
]}

White, R. A. ^{[19
]}

da Silva, S. P. ^{[19
]}

Rodrigues, A. P. ^{[20
]}

Larrauri, A. ^{[21
]}

Mazagatos, C. ^{[21
]}

Farah, A. ^{[22
]}

Carnahan, A. D. ^{[22
]}

Junker, C. ^{[23
]}

Sinnathamby, M. ^{[24
]}

Pebody, R. G. ^{[24
]}

Andrews, N. ^{[24
]}

Reynolds, A. ^{[25
]}

McMenamin, J. ^{[25
]}

Brown, C. S. ^{[26
]}

Adlhoch, C. ^{[27
]}

Penttinen, P. ^{[27
]}

Molbak, K. ^{[1
,28
]}

Krause, T. G. ^{[1
]}

机构：

[1] Statens Serum Inst, Copenhagen, Denmark

[2] Austrian Agcy Hlth & Food Safety, Vienna, Austria

[3] Sciensano, Brussels, Belgium

[4] Natl Inst Hlth Dev, Tallinn, Estonia

[5] Finnish Natl Inst Hlth & Welf, Helsinki, Finland

[6] French Publ Hlth Agcy, St Publ France, St Maurice, France

[7] Hellen Ctr Dis Control & Prevent, Athens, Greece

[8] Robert Koch Inst, Berlin, Germany

[9] Hess Landesprufungs & Untersuchungsamt Gesundheit, Dillenburg, Germany

[10] Natl Publ Hlth Inst, Budapest, Hungary

[11] Minist Human Capac, Budapest, Hungary

[12] Hlth Serv Execut Hlth Protect Surveillance Ctr, Dublin, Ireland

[13] Lazio ASL Roma 1, Dipartimento Epidemiol SSR, Rome, Italy

[14] Minist Salute, Rome, Italy

[15] Lab Natl Sante, Luxembourg, Luxembourg

[16] Directorate Hlth Informat & Res, Pieta, Malta

[17] Dept Hlth Regulat, Pieta, Malta

[18] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[19] Norwegian Inst Publ Hlth, Oslo, Norway

[20] Inst Nacl Saude Doutor Ricardo Jorge, Lisbon, Portugal

[21] Carlos III Hlth Inst, CIBER Epidemiol Salud Publ CIBERESP, Natl Ctr Epidemiol, Madrid, Spain

[22] Publ Hlth Agcy Sweden, Stockholm, Sweden

[23] Fed Stat Off, Neuchatel, Switzerland

[24] Publ Hlth England, Colindale, England

[25] Hlth Protect Scotland, Glasgow, Lanark, Scotland

[26] WHO, Reg Off Europe, Copenhagen, Denmark

[27] European Ctr Dis Prevent & Control, Solna, Sweden

[28] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Copenhagen, Denmark

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2019年 / 25卷 / 10期

关键词：

B/Yamagata; EuroMOMO; FluMOMO; Influenza; Mortality;

D O I：

10.1016/j.cmi.2019.02.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A( H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 ( 95% CI 25.0-25.8) per 100,000 population; 118.2 ( 116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A( H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered. (c) 2019 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license

引用

页码：1266 / 1276

页数：11

共 26 条

[1] Dominant influenza A(H3N2) and B/Yamagata virus circulation in EU/EEA, 2016/17 and 2017/18 seasons, respectively [J].