The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease

被引：37

作者：

Ling, Tan Sook ^{[1
]}

Chandrasegaran, Shanthini ^{[1
]}

Xuan, Low Zhi ^{[1
]}

Suan, Tong Li ^{[1
]}

Elaine, Elaine ^{[1
]}

Nathan, Durrgashini Visva ^{[2
]}

Chai, Yam Hok ^{[1
]}

Gunasekaran, Baskaran ^{[1
]}

Salvamani, Shamala ^{[2
]}

机构：

[1] UCSI Univ, Fac Appl Sci, Dept Biotechnol, 1 Jalan Puncak Menara Gading, Kuala Lumpur 56000, Malaysia

[2] Int Med Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, Kuala Lumpur 57000, Malaysia

来源：

BIOMED RESEARCH INTERNATIONAL | 2021年 / 2021卷

关键词：

DRUG-DELIVERY SYSTEM; NANOPARTICLES; MANAGEMENT; PROTEIN; BRAIN; STRATEGIES; PATHOLOGY; THERAPY;

D O I：

10.1155/2021/5550938

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer's disease. The available medication in the market has the ability to only slow down its progression. However, nanotechnology has shown its superiority that can be applied for medical usage and it has a great potential in the therapy of Alzheimer's disease, specifically in the disease diagnosis and providing an alternative approach to treat Alzheimer's disease. This is done by increasing the efficiency of drug delivery by penetrating and overcoming the blood-brain barrier. Having said that, there are limitations that need to be further investigated and researched in order to minimize the adverse effects and potential toxicity and to improve drug bioavailability. The recent advances in the treatment of Alzheimer's disease using nanotechnology include the regeneration of stem cells, nanomedicine, and neuroprotection. In this review, we will discuss the advancement of nanotechnology which helps in the diagnosis and treatment of neurodegenerative disorders such as Alzheimer's disease as well as its challenges.

引用

页数：9

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