MORAXELLA CATARRHALIS-SPECIFIC TH1 CELLS IN BAL FLUIDS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

被引：22

作者：

Amedei, A. ^{[1
,2
]}

Della Bella, C. ^{[1
]}

Niccolai, E. ^{[1
]}

Stanflin, N. ^{[3
]}

Benagiano, M. ^{[1
]}

Duranti, R. ^{[1
]}

Del Prete, G. ^{[1
,2
]}

Murphy, T. F. ^{[4
,5
]}

D'Elios, M. M. ^{[1
,2
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[2] Azienda Osped Univ Careggi, Dept Biomed, Florence, Italy

[3] Osped Univ Careggi, Florence, Italy

[4] Buffalo State Univ, Div Infect Dis, New York, NY USA

[5] Buffalo State Univ, Div Pulm & Crit Care Med, New York, NY USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2009年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

chronic obstructive pulmonary disease; Moraxella catarrhalis; specific T cell; Th1; IMMUNOGLOBULIN-SYNTHESIS; AIRWAY INFLAMMATION; PERIPHERAL-BLOOD; EMPHYSEMA; ACTIVATION; SMOKERS; STAT4;

D O I：

10.1177/039463200902200413

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In chronic obstructive pulmonary disease (COPD) patients' airway mucosa is infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied the antigen-specificity and the effector functions of in vivo activated T lymphocytes isolated from BAL (Bronchoalveolar lavage) of 5 Moraxella catarrhalis (Mc)-infected and 5 Mc-non-infected COPD patients. Mc-specific T cells were detected only in BAL or peripheral blood of Moraxella catarrhalis-infected patients. The majority of BAL Mc-specific T cells expressed the T helper type 1 (Th1) cytokine profile with high cytotoxic and pro-apoptotic activity. Upon antigen stimulation, all Me-specific T clones were able to help the immunoglobulin production by autologous B cells and the MMP (Matrix MetalloProteinase)-12 activity by monocytes. Our results suggest a role for Th1-driven response to Moraxella catarrhalis in the genesis of COPD.

引用

页码：979 / 990

页数：12

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