Access to cyclic gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

被引：22

作者：

Adouama, Cherif ^{[1
]}

Keyrouz, Robert ^{[1
]}

Pilet, Guillaume ^{[2
]}

Monnereau, Cyrille ^{[3
]}

Gueyrard, David ^{[1
]}

Noel, Timothy ^{[4
]}

Medebielle, Maurice ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, INSA, CPE Lyon,ICBMS,UMR 5246, 43,Bd 11 Novembre 1918, F-69622 Villeurbanne, France

[2] Univ Lyon 1, CNRS, LMI, UMR 5615, 43,Bd 11 Novembre 1918, F-69622 Villeurbanne, France

[3] Univ Lyon 1, CNRS UMR 5182, Ens Lyon, Lab Chim, F-69342 Lyon, France

[4] Eindhoven Univ Technol, Dept Chem Engn & Chem, Micro Flow Chem & Proc Technol, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 41期

关键词：

PHOTOREDOX CATALYSIS; MEDICINAL CHEMISTRY; DERIVATIVES; ALKALOIDS; FLUORINE; INDOLES;

D O I：

10.1039/c7cc02979a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of unprecedented scaffolds containing a difluoroacyl moiety were obtained in moderate to good yields, with excellent diastereoselectivity, via electrochemical or photochemical activation of difluoroacyl heteroaryles with a series of olefinic substrates.

引用

页码：5653 / 5656

页数：4

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