CANCER LKB1 cooperates with Sox17 to drive metastasis

被引：4
|
作者：
Kriaucionis, Skirmantas [1 ]
机构：
[1] Univ Oxford, Ludwig Inst Canc Res, Oxford, England
来源：
NATURE CELL BIOLOGY | 2021年 / 23卷 / 08期
基金：
英国生物技术与生命科学研究理事会;
关键词：
METABOLISM;
D O I：
10.1038/s41556-021-00730-w
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
LKB1 is frequently mutated in lung, cervical and other types of cancers. To determine how LKB1 inactivation contributes to lung cancer progression, Pierce et al. employed a chromatin accessibility assay to reveal Sox17 as a key transcription factor downstream of LKB1, promoting lung cancer metastasis.
引用
收藏
页码：816 / 817
页数：2
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