Clinical trials and systematic reviews addressing similar interventions for the same condition do not consider similar outcomes to be important: a case study in HIV/AIDS

被引：22
作者：
Saldanha, Ian J. [1 ]
Li, Tianjing [2 ]
Yang, Cui [3 ]
Owczarzak, Jill [4 ]
Williamson, Paula R. [5 ]
Dickersin, Kay [6 ]
机构：
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 North Wolfe St,Room W6507-B, Baltimore, MD 21205 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 North Wolfe St,Room E6011, Baltimore, MD 21205 USA
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 2213 McElderry St,2nd Floor, Baltimore, MD 21205 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 624 North Broadway,Room 739, Baltimore, MD 21205 USA
[5] Univ Liverpool, Dept Biostat, MRC North West Hub Trials Methodol Res, Brownlow St, Liverpool L69 3GS, Merseyside, England
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 North Wolfe St,Room E6152, Baltimore, MD 21205 USA
来源：
JOURNAL OF CLINICAL EPIDEMIOLOGY | 2017年 / 84卷
基金：
美国国家卫生研究院;
关键词：
Clinical trials; Systematic reviews; Outcomes; HIV/AIDS; Core outcome sets; Outcome selection; RANDOMIZED CONTROLLED-TRIALS; ADHERENCE; CALL; BIAS; SETS; HIV;
D O I：
10.1016/j.jclinepi.2017.02.005
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Background: The usefulness of clinical trials and systematic reviews is compromised when they report different outcomes. We compared outcomes in reviews of HIV/AIDS and the trials included in the reviews. Study Design and Setting: We examined all Cochrane reviews of HIV/AIDS (as of June 2013) that included >= 1 trial and the trials that the reviews included. We compared outcomes within subgroups defined by type of intervention: clinical management, biomedical prevention, behavioral prevention, and health services. Results: We included 84 reviews that encompassed 524 trials. Although the median number of outcomes per trial (8) and per review (7.5) was similar, the trials reported a considerably greater number of unique outcomes than the reviews (779 vs. 218), ranging from 2.3 times greater (clinical management) to 5.4 times greater (behavioral prevention). High proportions of trial outcomes were not in any review: 68% (clinical management) to 83% (behavioral prevention). Lower proportions of review outcomes were not in any trial: 11% (clinical management) to 39% (health services). Conclusion: Outcomes in trials and reviews are not well aligned for appropriate inclusion of trial results in reviews and meta-analyses. Differences in perspectives, goals, and constraints between trialists and reviewers may explain differences in outcomes they consider important. (C) 2017 The Authors. Published by Elsevier Inc.
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收藏
页码：85 / 94
页数：10
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